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High expression of skp2 correlates with poor prognosis in endometrial endometrioid adenocarcinoma

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Abstract

Purpose: Skp2 interacts with the degradation of cyclin-dependent kinase inhibitor p27. This study aimed to investigate the correlation of skp2 expression with the expression of p27 and other cell cycle regulators, and clinicopathological parameters in endometrial endometrioid adenocarcinoma. Methods: Tissue samples of 136 endometrioid adenocarcinomas, in addition to 20 endometrial hyperplasias and 20 normal endometria, were immunohistochemically stained for skp2. The expression was represented as a labeling index (LI), which indicates the percentage of positive nuclei. Results: Skp2 staining was localized in the nuclei of the glandular cells of the proliferative phase endometrium, and endometrial hyperplasia and carcinoma cells. Skp2 expression was increased significantly in those of higher histological grade. The high level of skp2 expression was significantly correlated with the presence of lymph node metastasis and lymph-vascular space involvement. The LI of skp2 in endometrial carcinoma was significantly correlated with that of p27, Ki-67, cdk2, cyclin A, cyclin D1, cyclin E, p53 and PTEN. The high level of skp2 expression (LI≧20%) was significantly correlated with the patients’ poor survival. Conclusions: The skp2 level might have increased due to p27 accumulation and may be a good indicator of proliferative activity and poor prognosis.

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Acknowledgements

This work supported by grants-in-aid for Project Research of the Graduate School of Medical Sciences, Kitasato University (Grants 2005 and 4007) and for Scientific Research from the Ministry of Education, Culture, Sports, Sciences and Technology (Grants 12670176 and 12671627), Japan.

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Authors and Affiliations

  1. Department of Clinical Cytology, Graduate School of Medical Sciences, Kitasato University, Kanagawa, Japan

    Yuko Kamata, Yukari Nishimura, Tsutomu Arai, Miwa Kawaguchi, Akane Obokata & Hiroyuki Kuramoto

  2. Department of Pathology, School of Medicine, Kitasato University, Kanagawa, Japan

    Jun Watanabe

  3. Department of Obstetrics and Gynecology, School of Medicine, Kitasato University, Kanagawa, Japan

    Hiroyuki Kuramoto

  4. Department of Clinical Cytology, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan

    Manabu Hattori & Hiroyuki Kuramoto

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  1. Yuko Kamata
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  2. Jun Watanabe
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  3. Yukari Nishimura
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  4. Tsutomu Arai
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Correspondence to Yuko Kamata.

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Kamata, Y., Watanabe, J., Nishimura, Y. et al. High expression of skp2 correlates with poor prognosis in endometrial endometrioid adenocarcinoma. J Cancer Res Clin Oncol 131, 591–596 (2005). https://doi.org/10.1007/s00432-005-0671-2

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  • DOI: https://doi.org/10.1007/s00432-005-0671-2

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