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Hemodynamic alterations recorded by electrical cardiometry during ligation of ductus arteriosus in preterm infants

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Abstract

This is a prospective study using non-invasive electrical cardiometry to measure hemodynamic changes during surgical ligation of patent ductus arteriosus (PDA) in very low birth weight (VLBW, ≤1500 g) infants. The aims of this study were to examine hemodynamic aberration caused by abrupt closure of a ductal shunting and to define factors that affect hemodynamic changes. Simultaneous measurements of heart rate (HR), stroke volume (SV), cardiac output (CO), and systemic vascular resistance (SVR) were collected at ten time points: 1 h prior to anesthesia, at the beginning of anesthesia, starting of surgery, immediately after PDA being ligated, and 1 h followed by 6, 12, 18, 24, and 48 h after the surgery. Thirty infants with gestational age of 27.7 ± 2.0 weeks and birth weight of 929 ± 280 g were studied. Upon sudden termination of ductal shunting, there was a significant decline in CO to 73 % of presurgery baseline. The deterioration in CO was associated with a decreased SV rather than HR. At the same time, there was an increase of SVR following ductal ligation. Magnitude of CO and SV reduction were higher in smaller infants (≤1 kg), and recovery was to a lesser degree in infants with more severe PDA.

Conclusion: Reduced stroke volume and elevated vascular resistance contribute to the major hemodynamic aberrations in VLBW infants receiving PDA ligation surgery.

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Abbreviations

CO:

Cardiac output

EC:

Electrical cardiometry

PDA:

Patent ductus arteriosus

SV:

Stroke volume

VLBW:

Very low birth weight

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Acknowledgments

The authors are grateful to the Statistics Center for Clinical Research of Chang Gung Memorial Hospital for their assistance in statistical analyses.

Conflict of interest

The authors declare that there are no conflicts of interest in this study.

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Authors and Affiliations

  1. Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, Taoyuan, Taiwan

    Reyin Lien & Kai-Hsiang Hsu

  2. Division of Cardiovascular Surgery, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, Tauyuan, Taiwan

    Jaw-Ji Chu & Yu-Sheng Chang

Authors
  1. Reyin Lien
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  2. Kai-Hsiang Hsu
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  3. Jaw-Ji Chu
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  4. Yu-Sheng Chang
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Corresponding author

Correspondence to Reyin Lien.

Additional information

Communicated by Patrick Van Reempts

Reyin Lien and Kai-Hsiang Hsu contributed equally to this work.

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Lien, R., Hsu, KH., Chu, JJ. et al. Hemodynamic alterations recorded by electrical cardiometry during ligation of ductus arteriosus in preterm infants. Eur J Pediatr 174, 543–550 (2015). https://doi.org/10.1007/s00431-014-2437-9

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  • DOI: https://doi.org/10.1007/s00431-014-2437-9

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