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Persistent pure red cell aplasia in dicygotic twins with persistent congenital parvovirus B19 infection—remission following high dose intravenous immunoglobulin

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Abstract

We report the course of dicygotic twins born preterm after 29 4/7 weeks of gestation due to congenital Parvovirus B19 infection causing fetal hydrops with severe anemia in one infant in whom intrauterine transfusion was impossible to perform and high levels of viremia in both infants. After being discharged, they were readmitted at 3 months of age with critical aplastic crisis. Therapy with intravenous immunoglobulin infusion resulted in decreasing viremia followed by stable hemoglobin levels in both infants.

Conclusion: Intravenous immunoglobulin treatment of congenital pure red cell aplasia due to Parvovirus B19 infection in preterm infants seems to be effective to introduce viral remission and to normalize erythropoiesis.

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Abbreviations

B19V:

Parvovirus B19

IVIG:

Intravenous immunoglobulin

PCR:

Polymerase chain reaction

Rbc:

Red blood cell

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Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Pediatric Pulmonology/Immunology, Charité University Medical Center Berlin, Berlin, Germany

    Alice Lejeune & Horst von Bernuth

  2. Department of Neonatology, Charité University Medical Center Berlin, Berlin, Germany

    Malte Cremer & Christoph Bührer

  3. Labor Berlin—Charité Vivantes GmbH, Berlin, Germany

    Anke Edelmann

  4. Institute of Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany

    Susanne Modrow

  5. Klinik für Pädiatrie m. S. Pneumologie und Immunologie, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany

    Alice Lejeune

Authors
  1. Alice Lejeune
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  2. Malte Cremer
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  3. Horst von Bernuth
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  4. Anke Edelmann
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  5. Susanne Modrow
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  6. Christoph Bührer
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Corresponding author

Correspondence to Alice Lejeune.

Additional information

Communicated by David Nadal

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Lejeune, A., Cremer, M., von Bernuth, H. et al. Persistent pure red cell aplasia in dicygotic twins with persistent congenital parvovirus B19 infection—remission following high dose intravenous immunoglobulin. Eur J Pediatr 173, 1723–1726 (2014). https://doi.org/10.1007/s00431-014-2420-5

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  • DOI: https://doi.org/10.1007/s00431-014-2420-5

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