Abstract
Congenital leukemia is a rare disease with particular biological and clinical characteristics which differs from those of older children and adults. Here, we describe two cases of congenital acute lymphoblastic leukemia in two newborns with different clinical presentations (leukemia cutis vs. splenomegaly and respiratory distress) and fatal outcome. Both cases shared the expression of myeloid antigens (CD65) and cytogenetic disorders involving the MLL gene (location 11q23) which are associated to extremely poor prognosis.
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Abbreviations
- AML:
-
Acute myeloblastic leukemia
- ALL:
-
Acute lymphoblastic leukemia
- CSF:
-
Cerebrospinal fluid
- BMA:
-
Bone marrow aspiration
- INTERFANT:
-
International collaborative treatment protocol for infants under 1 year with acute lymphoblastic leukemia
- TMS:
-
Transient myeloproliferative syndrome
- MRD:
-
Minimal residual disease
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Bas Suárez, M.P., López Brito, J., Santana Reyes, C. et al. Congenital acute lymphoblastic leukemia: a two-case report and a review of the literature. Eur J Pediatr 170, 531–534 (2011). https://doi.org/10.1007/s00431-010-1339-8
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DOI: https://doi.org/10.1007/s00431-010-1339-8