Skip to main content

Advertisement

SpringerLink
Log in

Congenital B-cell Acute Lymphoblastic Leukemia with Congenital Rubella Infection

  • Case Report
  • Published:
Indian Pediatrics Aims and scope Submit manuscript

Abstract

Objective

Congenital B-cell Acute lymphoblastic leukemia (ALL) is a rare malignancy.

Case Characteristics

A newborn infant presented with purpuric spots and ecchymotic patches, blueberry muffin rash, depressed neonatal reflexes, respiratory distress and hepatosplenomegaly. Peripheral smear revealed atypical blast cells. Serum ELISA was positive for Rubella IgM and IgG antibodies. Flow cytometry suggested congenital B-cell ALL.

Outcome

The baby died after 3 days due to suspected intracranial hemorrhage.

Message

Congenital leukemia may be rarely associated with congenital rubella infection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bajwa RP, Skinner R, Windebank KP, Reid MM. Demographic study of leukaemia presenting within the first 3 months of life in the Northern Health Region of England. J Clin Pathol. 2004;57:186–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Prakash KP, Rau AT, Prakash KP, Rau AT, Bhat ST, Rau AR, et al. Congenital leukemia-A diagnostic dilemma. Indian J Med Paediatr Oncol. 2008;29:41–3.

    Article  Google Scholar 

  3. Resnick KS, Brod BB. Leukemia cutis in congenital leukemia: Analysis and review of the world literature with report of an additional case. Arch Dermatol. 1993;129:1301–6.

    Article  Google Scholar 

  4. Mehta V, Balachandran C, Lonikar V. Blueberry muffin baby: A pictoral differential diagnosis. Dermatol Online J. 2008;14:8.

    PubMed  Google Scholar 

  5. Li FP, Bader JL. Oncology-epidemiology of selected childhood cancers. In: Nathan DG, Oski FA, eds. Haematology of Infancy and Childhood: Philadelphia: WB Saunders, 1987:p. 918–41.

  6. Hohlfeld P, Forestier F, Kaplan C, Tissot JD, Daffos F. Fetal thrombocytopenia: A retrospective survey of 5,194 fetal blood samplings. Blood. 1994;84:1851–6.

    CAS  PubMed  Google Scholar 

  7. Franco SA, Riley HD, Jr, Chitwood LA. The congenital rubella syndrome. South Med J. 1970;63:825–30.

    Article  CAS  PubMed  Google Scholar 

  8. Stewart A, Webb J, Hewitt D. A survey of childhood malignancies. Br Med J. 1958;1:1497–508.

    Google Scholar 

  9. Kelly SJ, Gibbs T, Cheetham CH. Acute myelomonocytic leukaemia following atypical congenital rubella. J Clin Pathol. 1993;46:764–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Mangala Prasad V, Klose T, Rossmann MG. Assembly, maturation and three dimensional helical structure of the teratogenic rubella virus. PLoS Pathog. 2017; 13:e1006377.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Sir Padampat Mother and Child Health Institute, JK Lon Hospital, SMS Medical College, Jaipur, Rajasthan, India

    Dhan Raj Bagri, Krapal Singh Yadav & Rambabu Sharma

  2. Department of Pathology, Sir Padampat Mother and Child Health Institute, JK Lon Hospital, SMS Medical College, Jaipur, Rajasthan, India

    Sandhya Gulati

  3. Departments of Pediatrics, SMS Medical College, Jaipur, Rajasthan, India

    Dhan Raj Bagri

Authors
  1. Dhan Raj Bagri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Krapal Singh Yadav
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rambabu Sharma
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sandhya Gulati
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dhan Raj Bagri.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bagri, D.R., Yadav, K.S., Sharma, R. et al. Congenital B-cell Acute Lymphoblastic Leukemia with Congenital Rubella Infection. Indian Pediatr 56, 67–68 (2019). https://doi.org/10.1007/s13312-019-1471-0

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13312-019-1471-0

Keywords

Search

Navigation