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Influence of maternal smoking on neonatal aortic intima-media thickness, serum IGF-I and IGFBP-3 levels

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Abstract

Epidemiological studies have reported associations between a range of cardiovascular risk factors such as smoking and intima-media thickness (IMT). Some reports indicate that the maternal tobacco smoking causes disturbances of the endocrine status of the foetus. There are several potential mechanisms by which insulin-like growth factor I (IGF-I) could modify atherosclerotic processes either locally or in a systemic manner. The aim of this study was to investigate the influence of maternal smoking on neonatal aortic IMT (aIMT), serum IGF-I and IGF-binding protein-3 (IGFBP-3) levels. Aortic intima-media thickness was measured in 28 neonates whose mothers smoked during the pregnancy and 28 control neonates. Mean and weight-adjusted aIMT were significantly greater in the neonates whose mothers smoked (0.455 ± 0.009 mm and 0.151 ± 0.005 mm/kg, respectively) than in controls (0.403 ± 0.029 mm and 0.118 ± 0.014 mm/kg, respectively). Birth-weight of newborns whose mothers smoked was less than that of the controls. The decreases in serum IGF-I and IGFBP-3 observed in the infants whose mothers smoked were non-significant. Mean aIMT was negatively associated with birth-weight and IGF-I level. In conclusion, neonates whose mothers smoked have significantly increased aIMT. It might play a role in the pathogenesis of atherosclerosis in adult life.

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Acknowledgements

This study was supported by Erciyes University Research Fund.

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Authors and Affiliations

  1. Department of Paediatrics, Division of Neonatology,, School of Medicine, Erciyes University, Kayseri, Turkey

    Tamer Gunes, Esad Koklu, Mehmet Adnan Ozturk, Mustafa Akcakus, Selim Kurtoglu & Selmin Koklu

  2. Department of Radiology, School of Medicine,Erciyes University, Kayseri, Turkey

    Ali Yikilmaz & Abdulhakim Coskun

  3. Division of Paediatric Radiology, School of Medicine,Erciyes University, Kayseri, Turkey

    Ali Yikilmaz & Abdulhakim Coskun

  4. Division of Paediatric Endocrinology and Metabolism, School of Medicine, Erciyes University, Kayseri, Turkey

    Selim Kurtoglu

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  1. Tamer Gunes
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  2. Esad Koklu
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  3. Ali Yikilmaz
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Correspondence to Esad Koklu.

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Gunes, T., Koklu, E., Yikilmaz, A. et al. Influence of maternal smoking on neonatal aortic intima-media thickness, serum IGF-I and IGFBP-3 levels. Eur J Pediatr 166, 1039–1044 (2007). https://doi.org/10.1007/s00431-006-0376-9

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  • DOI: https://doi.org/10.1007/s00431-006-0376-9

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