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Proteomics dedicated to biofilmology: What have we learned from a decade of research?

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Abstract

Advances in proteomics techniques over the past decade, closely integrated with genomic and physicochemical approach, have played a great role in developing knowledge of the biofilm lifestyle of bacteria. Despite bacterial proteome versatility, many studies have demonstrated the ability of proteomics approaches to elucidating the biofilm phenotype. Though these investigations have been largely used for biofilm studies in the last decades, they represent, however, a very low percentage of proteomics works performed up to now. Such approaches have offered new targets for combating microbial biofilms by providing a comprehensive quantitative and qualitative overview of their protein cell content. Herein, we summarized the state of the art in knowledge about biofilm physiology after one decade of proteomic analysis. In a second part, we highlighted missing research tracks for the next decade, emphasizing the emergence of posttranslational modifications in proteomic studies stemming from recent advances in mass spectrometry-based proteomics.

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Abbreviations

MS:

Mass spectrometry

2D-E:

Two-dimensional electrophoresis

CF:

Cystic fibrosis

PTMs:

Posttranslational modifications

EPS:

Extracellular polymeric substances

OMVs:

Outer membrane vesicles

QS:

Quorum sensing

AHLs:

Acyl homoserine lactones

OMP:

Outer membrane protein

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Acknowledgments

Grant: program number 33267 FEDER/CNRS.

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Authors and Affiliations

  1. CNRS, UMR 6270, Laboratory “Polymères, Biopolymères, Surfaces”, 76820, Mont-Saint-Aignan, France

    Arbia Khemiri, Thierry Jouenne & Pascal Cosette

  2. University of Normandy, UR, Mont-Saint-Aignan, France

    Arbia Khemiri, Thierry Jouenne & Pascal Cosette

  3. PISSARO Proteomic Facility, IRIB, 76820, Mont-Saint-Aignan, France

    Arbia Khemiri, Thierry Jouenne & Pascal Cosette

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  1. Arbia Khemiri
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  2. Thierry Jouenne
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Correspondence to Arbia Khemiri.

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Khemiri, A., Jouenne, T. & Cosette, P. Proteomics dedicated to biofilmology: What have we learned from a decade of research?. Med Microbiol Immunol 205, 1–19 (2016). https://doi.org/10.1007/s00430-015-0423-0

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