Skip to main content
SpringerLink
Log in

Juvenile trabecular ossifying fibroma: an update

  • Original Article
  • Published:
Virchows Archiv Aims and scope Submit manuscript

Abstract

Fibro-osseous lesions are characterized by the presence of bone marrow that has changed into fibrous tissue and that contains mineralized material of varying appearances. Because of overlapping clinical, radiological, and histopathological features, their classification has evoked much discussion. The current classification recognizes fibrous dysplasia, ossifying fibroma, and osseous dysplasia. Juvenile trabecular ossifying fibroma is a rare variant of ossifying fibroma that is clinically characterized by rapid growth that may suggest malignancy. A series of 15 cases is reported with emphasis on a hitherto unnoticed histological feature that may be helpful in recognizing this lesion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10

Similar content being viewed by others

References

  1. Brannon RB, Fowler CB (2001) Benign fibro-osseous lesions: a review of current concepts. Adv Anat Pathol 8:126–143

    Article  PubMed  CAS  Google Scholar 

  2. Slootweg PJ (1996) Maxillofacial fibro-osseous lesions: classification and differential diagnosis. Semin Diagn Pathol 13:104–112

    PubMed  CAS  Google Scholar 

  3. Voytek TM, Ro JY, Eideken J et al (1995) Fibrous dysplasia and cemento-ossifying fibroma. A histologic spectrum. Am J Surg Pathol 19:775–781

    Article  PubMed  CAS  Google Scholar 

  4. Pollandt K, Engels C, Kaiser E, Werner M, Delling G (2001) Gsα gene mutations in monostotic fibrous dysplasia of bone and fibrous dysplasia-like low-grade central osteosarcoma. Virchows Arch 439:170–175

    Article  PubMed  CAS  Google Scholar 

  5. Toyosawa S, Yuki M, Kishino M et al (2007) Ossifying fibroma vs fibrous dysplasia of the jaw: molecular and immunological characterization. Mod Pathol 20:389–396

    Article  PubMed  CAS  Google Scholar 

  6. El-Mofty SK (2002) Psammomatoid and trabecular juvenile ossifying fibroma of the craniofacial skeleton: two distinct clinicopathologic entities. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93:296–304

    Article  PubMed  Google Scholar 

  7. Slootweg PJ, Panders AK, Koopmans R, Nikkels PGJ (1994) Juvenile ossifying fibroma. An analysis of 33 cases with emphasis on histopathological aspects. J Oral Pathol Med 23:385–388

    Article  PubMed  CAS  Google Scholar 

  8. Slootweg PJ, El-Mofty SK (2005) Ossifying fibroma. In: Barnes L, Eveson JW, Reichart PA, Sidransky D (eds) World Health Organization classification of tumours. Pathology and genetics of tumours of the head and neck. IARC, Lyon, pp 319–320

    Google Scholar 

Download references

Conflict of interest

I declare that I have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Pathology 824, Radboud University Nijmegen Medical Center, PO box 9101, 6500 HB, Nijmegen, Netherlands

    Pieter J. Slootweg

Authors
  1. Pieter J. Slootweg
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pieter J. Slootweg.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Slootweg, P.J. Juvenile trabecular ossifying fibroma: an update. Virchows Arch 461, 699–703 (2012). https://doi.org/10.1007/s00428-012-1329-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00428-012-1329-5

Keywords

Search

Navigation