Abstract
Benign fibro-osseous lesions within the maxillofacial region represent a heterogeneous group of benign entities with overlapping histologic features. Ossifying fibroma, the rarest of these entities, represents a true neoplasm. Juvenile ossifying fibroma (JOF) is considered an aggressive rapidly growing sub-type. It tends to occur in the first or second decades of life. Based on histological and clinical features it can further be classified into two variants, namely juvenile trabecular ossifying fibroma (JTOF) and juvenile psammomatoid ossifying fibroma (JPOF). JTOF features a proliferation of cellular fibroblastic tissue admixed with woven bone trabeculae with varying histologic presentations. Correlation with clinical and radiographic features is essential to differentiate it from other fibro-osseous lesions. A case of JTOF of the mandible is exemplified in this Sine Qua Non Radiology-Pathology article.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of retrospective case report, formal consent is not required. The tumor tissue included in the manuscript was obtained as part of the standard of care for the patient and retrospectively collected for the case report.
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No identifer information is included in the case report, and the study meets the waiver criteria for the institutional review board of University of Maryland Baltimore.
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Sultan, A.S., Schwartz, M.K., Caccamese, J.F. et al. Juvenile Trabecular Ossifying Fibroma. Head and Neck Pathol 12, 567–571 (2018). https://doi.org/10.1007/s12105-017-0862-6
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DOI: https://doi.org/10.1007/s12105-017-0862-6