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Gene expression profiling for the investigation of soft tissue sarcoma pathogenesis and the identification of diagnostic, prognostic, and predictive biomarkers

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Abstract

Soft tissue sarcomas are malignant neoplasms derived from mesenchymal tissues. Their pathogenesis is poorly understood and there are few effective treatment options for advanced disease. In the past decade, gene expression profiling has been applied to sarcomas to facilitate understanding of sarcoma pathogenesis and to identify diagnostic, prognostic, and predictive markers. In this paper, we review this body of work and discuss how gene expression profiling has led to advancements in the understanding of sarcoma pathobiology, the identification of clinically useful biomarkers, and the refinement of sarcoma classification schemes. Lastly, we conclude with a discussion of strategies to further optimize the translation of gene expression data into a greater understanding of sarcoma pathogenesis and improved clinical outcomes for sarcoma patients.

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Authors and Affiliations

  1. Pathology Department, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA, 94305, USA

    Andrew H. Beck, Robert B. West & Matt van de Rijn

  2. Pathology and Laboratory Service, Palo Alto Veterans Affairs Health Care System, Palo Alto, CA, USA

    Robert B. West

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  1. Andrew H. Beck
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  2. Robert B. West
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Correspondence to Matt van de Rijn.

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Beck, A.H., West, R.B. & van de Rijn, M. Gene expression profiling for the investigation of soft tissue sarcoma pathogenesis and the identification of diagnostic, prognostic, and predictive biomarkers. Virchows Arch 456, 141–151 (2010). https://doi.org/10.1007/s00428-009-0774-2

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