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Cytokeratin 7/20 and mucin core protein expression in ulcerative colitis-associated colorectal neoplasms

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Abstract

Different histogenetic pathways have been suggested between ulcerative colitis (UC)-associated neoplasia and sporadic colorectal neoplasia. Little is known about the cytokeratin (CK) and mucin expression in UC-associated neoplasms. To clarify the characteristics of UC-associated colorectal carcinogenesis, we examined the immunohistochemical expression of CK7, CK20, MUC2, MUC5AC and MUC6 in 90 colorectal neoplasms, including 22 UC-associated adenocarcinomas (colitic cancer; CC), ten high-grade dysplasias (HGD) in UC, nine low-grade dysplasias (LGD) in UC, 24 sporadic tubular adenomas (TA) and 25 adenocarcinomas (AC). CK7 was positive in most of UC-associated neoplasms: 59% of CC cases, 80% of HGD and 89% of LGD, respectively, whereas, in non-UC associated neoplasia, 21% of TA and 12% of AC. The frequency of MUC6 expression in UC-associated neoplasia was 32% in CC, 30% in HGD and 44% in LGD, respectively, whereas, in non-UC associated neoplasia, 4.2% in TA and 0% in AC. MUC5AC expression in UC-associated neoplasia was detectable in 73% of CC, 90% of HGD and 89% of LGD, respectively; in non-UC associated neoplasia 67% in AC and 20% in TA. There were obvious differences in the expression of CK7 and MUC6 between UC-associated neoplasms and sporadic tumors. The incidence of MUC5AC expression in UC-associated neoplasms was also higher than sporadic tumors. These results suggest that gastric-type mucins play an important role in the initial step of CC-tumorigenesis, and CK7 and gastric-type mucins may be useful in the differential diagnosis between UC-associated neoplasms and sporadic ones.

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Authors and Affiliations

  1. Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kamigyo-ku, 602-8566, Kyoto, Japan

    Natsuko Tatsumi & Takeshi Okanoue

  2. Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu, 520-2192, Shiga, Japan

    Ryoji Kushima, Rie Kakinoki & Hidetoshi Okabe

  3. Klinikum Bayreuth, Institute of Pathology, 95445, Bayreuth, Germany

    Michael Vieth & Manfred Stolte

  4. Department of Pathology, Shiga University of Medical Science, Otsu, 520-2192, Shiga, Japan

    Ken-ichi Mukaisho & Takanori Hattori

  5. Klinikum Aschaffenburg, Institute of Pathology, 63739, Aschaffenburg, Germany

    Franz Borchard

Authors
  1. Natsuko Tatsumi
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  2. Ryoji Kushima
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  3. Michael Vieth
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  4. Ken-ichi Mukaisho
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  5. Rie Kakinoki
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  6. Hidetoshi Okabe
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  7. Franz Borchard
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  9. Takeshi Okanoue
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  10. Takanori Hattori
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Correspondence to Ryoji Kushima.

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Tatsumi, N., Kushima, R., Vieth, M. et al. Cytokeratin 7/20 and mucin core protein expression in ulcerative colitis-associated colorectal neoplasms. Virchows Arch 448, 756–762 (2006). https://doi.org/10.1007/s00428-006-0188-3

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  • DOI: https://doi.org/10.1007/s00428-006-0188-3

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