Abstract
D2-40 is a monoclonal antibody, which reacts with a fixative-resistant epitope of lymphatic endothelium. Sinonasal-type hemangiopericytoma (SHP) and tumors of the (conventional) hemangiopericytoma/solitary fibrous tumor family (HP/SFT) are characterized by prominent vasculature. However, data concerning D2-40 labeling of these tumors are very sparse. In the present study, we investigated D2-40 staining in tissue specimens of 17 patients with SHP (male to female ratio of 2.4:1, median age of 63 years) and compared the immunolabeling with 20 cases of HP/SFT, including three SFT cases from nasal mucosa. D2-40 was detected in vascular channels of all SHP patients examined. By contrast, all cases of HP/SFT did not reveal any vascular channel being positive for D2-40, neither in the nasal cases nor in the remaining patients. This study presented for the first time data on D2-40 labeling in a series of SHP, HP/SFT, and supports the distinction of SHP from HP/SFT.
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Acknowledgements
We wish to thank Mrs. Bergholz, Mrs. Geier, and Mrs. Pelzer (Institute of Pathology, University of Jena) for their excellent technical assistance. We acknowledge the support of Mrs. Gröschel (Tumor Registry, Jena) for providing case data from the consultation files. Special thanks to Dr. Alexander Berndt, (Institute of Pathology, University of Jena) for technical assistance in preparing the figures.
We are very grateful to all pathologists who sent case material and clinical details from patients included in this study.
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Hansen, T., Katenkamp, K. & Katenkamp, D. D2-40 staining in sinonasal-type hemangiopericytoma—further evidence of distinction from conventional hemangiopericytoma and solitary fibrous tumor. Virchows Arch 448, 459–462 (2006). https://doi.org/10.1007/s00428-005-0130-0
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DOI: https://doi.org/10.1007/s00428-005-0130-0