Skip to main content
Log in

Masking visual stimuli by transcranial magnetic stimulation

  • Original Article
  • Published:
Psychological Research Aims and scope Submit manuscript

Abstract

Transcranial magnetic stimulation (TMS) applied over the occipital pole can suppress visual perception. Since its first description in 1989 by Amassian et al., this technique has widely been used to investigate visual processing at the cortical level. This article presents a review of experiments masking visual stimuli by TMS. The psychophysical characterization of TMS masking, the dependence on stimulus onset asynchrony between visual stimulus and TMS pulse, and the topography of masking within the visual field are considered. The relation between visual masking and the generation of phosphenes is discussed as well as the underlying physiological mechanisms.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  • Amassian, V. E., Cracco, R. Q., Maccabee, P. J., Cracco, J. B., Rudell, A., & Eberle, L. (1989). Suppression of visual perception by magnetic coil stimulation of human occipital cortex. Electroencephalography & Clinical Neurophysiology, 74, 458–462.

    Article  Google Scholar 

  • Amassian, V. E., Cracco, R. Q., Maccabee, P. J., Cracco, J. B., Rudell, A. P., & Eberle, L. (1993). Unmasking human visual perception with the magnetic coil and its relationship to hemispheric asymmetry. Brain Research, 605, 312–316.

    Article  PubMed  Google Scholar 

  • Amassian, V. E., Maccabee, P. J., Cracco, R. Q., Cracco, J. B., Somasundaram, M., & Rothwell, J. C., et al. (1994). The polarity of the induced electric field influences magnetic coil inhibition of human visual cortex: Implications for the site of excitation. Electroencephalography and clinical Neurophysiology, 93, 21–26.

    Article  PubMed  Google Scholar 

  • Arroyo, S., Lesser, R. P., Poon, W. T., Webber, W. R. S., & Gordon, B. (1997). Neuronal generators of visual-evoked potentials in humans - visual processing in the human cortex. Epilepsia, 38, 600–610.

    Article  PubMed  Google Scholar 

  • Ashbridge, E., Walsh, V., & Cowey, A. (1997). Temporal aspects of visual-search studied by transcranial magnetic stimulation. Neuropsychologia, 35, 1121–1131.

    Article  PubMed  Google Scholar 

  • Barker, A. T., Jalinous, R., & Freeston, I. L. (1985). Non-invasive magnetic stimulation of human motor cortex. The Lancet, I, 1106–1107.

    Article  Google Scholar 

  • Beckers, G., & Hömberg, V. (1991). Impairment of visual perception and visual short term memory scanning by transcranial magnetic stimulation of occipital cortex. Experimental Brain Research, 87, 421–432.

    Article  Google Scholar 

  • Beckers, G., & Hömberg, V. (1992). Cerebral visual motion blindness: Transitory akinetopsia induced by transcranial magnetic stimulation of human area V5. Proceedings of the Royal Society London B, 249, 173–178.

    Article  Google Scholar 

  • Beckers, G., & Zeki, S. (1995). The consequences of inactivating areas V1 and V5 on visual motion perception. Brain, 118, 49–60.

    Article  PubMed  Google Scholar 

  • Bolz, J., Rosner, G., & Wässle, H. (1982). Response latency of brisk-sustained (X) and brisk-transient (Y) cells in the cat retina. Journal of Physiology (London), 382, 171–190.

    Google Scholar 

  • Corthout, E., Uttl, B., Walsh, V., Hallett, M., & Cowey, A. (1999). Timing of activity in early visual cortex as revealed by transcranial magnetic stimulation. Neuroreport, 10, 2631–2634.

    Article  PubMed  Google Scholar 

  • Corthout, E., Uttl, B., Juan, C. H., Hallett, M., & Cowey, A. (2000) Suppression of vision by transcranial magnetic stimulation: A third mechanism. Neuroreport, 11, 2345–2349.

    Article  PubMed  Google Scholar 

  • Corthout, E., Hallett, M., & Cowey, A. (2002). Early visual cortical processing suggested by transcranial magnetic stimulation. NeuroReport, 13, 1163–1166.

    Article  PubMed  Google Scholar 

  • Corthout, E., Hallett, M., & Cowey, A. (2003). Interference with vision by TMS over the occipital pole: A fourth period. Neuroreport, 14, 651–655.

    Article  PubMed  Google Scholar 

  • Desmurget, M., Epstein, C. M., Turner, R. S., Prablanc, C., Alexander, G. E., & Grafton, S. T. (1999). Role of the posterior parietal cortex in updating raching movements to a visual target. Nature Neuroscience, 2, 563–567.

    Article  PubMed  Google Scholar 

  • Epstein, C. M., & Zangaladze, A. (1996). Magnetic coil suppression of extrafoveal visual perception using disappearance targets. Journal of Clinical Neurophysiology, 13, 242–246.

    Article  PubMed  Google Scholar 

  • Ferbert, A., Priori, A., Rothwell, J. C., Day, B. L., Colebatch, J. G., & Marsden, C. D. (1992). Interhemispheric inhibition of the human motor cortex. Journal of Physiology, 453, 525–546.

    PubMed  Google Scholar 

  • Herzog, M. H., & Koch, C. (2001). Seeing properties of an invisible object: Feature inheritance and shine-through. Proceedings of the National Academy of Sciences of the United States of America, 98, 4271–4275.

    Article  PubMed  Google Scholar 

  • Hochstein, S., & Ahissar, M. (2002). View from the top: Hierarchies and reverse hierarchies in the visual system. Neuron, 36, 791–804.

    Article  PubMed  Google Scholar 

  • Hotson, J., Braun, D., Herzberg, W., & Boman, D. (1994). Transcranial magnetic stimulation of extrastriate cortex degrades human motion direction discrimination. Vision Research, 34, 2115–2123.

    Article  PubMed  Google Scholar 

  • Ilic, T. V., Meintzschel, F., Cleff, U., Ruge, D., Kessler, K. R., & Ziemann, U. (2002). Short-interval paired-pulse inhibition and facilitation of human motor cortex: The dimension of stimulus intensity. Journal of Physiology-London, 545, 153–167.

    Article  Google Scholar 

  • Ilmoniemi, R. J., Virtanen, J., Ruohonen, J., Karhu, J., Aronen, H. J., & Näätänen, R., et al. (1997). Neuronal responses to magnetic stimulation reveal cortical reactivity and connectivity. Neuroreport, 8, 3537–3540.

    Article  PubMed  Google Scholar 

  • Kamitani, Y., & Shimojo, S. (1999). Manifestation of scotomas created by transcranial magnetic stimulation of human visual cortex. Nature Neuroscience, 2, 767–771.

    Article  PubMed  Google Scholar 

  • Kammer, T. (1999). Phosphenes and transient scotomas induced by magnetic stimulation of the occipital lobe: Their topographic relationship. Neuropsychologia, 37, 191–198.

    Article  PubMed  Google Scholar 

  • Kammer, T., & Beck, S. (2002). Phosphene thresholds evoked by transcranial magnetic stimulation are insensitive to short-lasting variations in ambient light. Experimental Brain Research, 145, 407–410.

    Article  Google Scholar 

  • Kammer, T., & Nusseck, H.G. (1998). Are recognition deficits following occipital lobe TMS explained by raised detection thresholds? Neuropsychologia, 36, 1161–1166.

    Article  PubMed  Google Scholar 

  • Kammer, T., Lehr, L., & Kirschfeld, K. (1999). Cortical visual processing is temporally dispersed by luminance in human subjects. Neuroscience Letters, 263, 133–136.

    Article  PubMed  Google Scholar 

  • Kammer, T., Beck, S., Thielscher, A., Laubis-Herrmann, U., & Topka, H. (2001a). Motor thresholds in humans. A transcranial magnetic stimulation study comparing different pulseforms, current directions and stimulator types. Clinical Neurophysiology, 112, 250–258.

    Article  Google Scholar 

  • Kammer, T., Beck, S., Erb, M., & Grodd, W. (2001b). The influence of current direction on phosphene thresholds evoked by transcranial magnetic stimulation. Clinical Neurophysiology, 112, 2015–2021.

    Article  Google Scholar 

  • Kammer, T., Scharnowski, F., & Herzog, M. H. (2003). Combining backward masking and transcranial magnetic stimulation in human observers. Neuroscience Letters, 343, 171–174.

    PubMed  Google Scholar 

  • Kammer, T., Puls, K., Strasburger, H., Hill, N. J., & Wichmann, F. A. (2005a). Transcranial magnetic stimulation in the visual system. I. The psychophysics of visual suppression. Experimental Brain Research, 160, 118–128.

    Article  Google Scholar 

  • Kammer, T., Puls, K., Erb, M., & Grodd, W. (2005b). Transcranial magnetic stimulation in the visual system. II. Characterization of induced phosphenes and scotomas. Experimental Brain Research, 160, 129–140.

    Article  Google Scholar 

  • Kastner, S., Demmer, I., & Ziemann, U. (1998). Transient visual field defects induced by transcranial magnetic stimulation over the occipital lobe. Experimental Brain Research, 118, 19–26.

    Article  Google Scholar 

  • Lavidor, M., & Walsh, V. (2004). Opinion—The nature of foveal representation. Nature Reviews Neuroscience, 5, 729–735.

    Article  PubMed  Google Scholar 

  • Lennie, P. (1981). The physiological basis of variations in visual latency. Vision Research, 21, 815–824.

    Article  PubMed  Google Scholar 

  • Marg, E., & Rudiak, D. (1994). Phosphenes induced by magnetic stimulation over the occipital brain: Description and probable site of stimulation. Optometry & Vision Science, 71, 301–311.

    Article  Google Scholar 

  • Masur, H., Papke, K., & Oberwittler, C. (1993). Suppression of visual perception by transcranial magnetic stimulation—experimental findings in healthy subjects and patients with optic neuritis. Electroencephalography and clinical Neurophysiology, 86, 259–267.

    Article  PubMed  Google Scholar 

  • Maunsell, J. H., & Gibson, J. R. (1992). Visual response latencies in striate cortex of the macaque monkey. Journal of Neurophysiology, 68, 1332–1344.

    PubMed  Google Scholar 

  • Meyer, B. U., Diehl, R. R., Steinmetz, H., Britton, T. C., & Benecke, R. (1991). Magnetic stimuli applied over motor cortex and visual cortex: Influence of coil position and field polarity on motor responses, phosphenes, and eye movements. Electroencephalography & Clinical Neurophysiology - Supplement, 43, 121–134.

    Google Scholar 

  • Miller, M. B., Fendrich, R., Eliassen, J. C., Demirel, S., & Gazzaniga, M. S. (1996). Transcranial magnetic stimulation—delays in visual suppression due to luminance changes. Neuroreport, 7, 1740–1744.

    Article  PubMed  Google Scholar 

  • Moliadze, V., Zhao, Y., Eysel, U. T., & Funke, K. (2003). Effect of transcranial magnetic stimulation on single-unit activity in the cat primary visual cortex. Journal of Physiology-London, 553, 665–679.

    Article  Google Scholar 

  • Nowak, L.G., & Bullier, J. (1997). The timing of information transfer in the visual system. In: K. S. Rockland, J. H. Kaas & A. Peters (eds.), Cerebral Cortex. Vol 12: Extrastriate Cortex in Primates, vol 12., New York, London: Plenum Press, pp 205–241.

  • Nowak, L. G., Munk, M. H. J., Girard, P., & Bullier, J. (1995). Visual latencies in areas V1 and V2 of the macaque monkey. Visual Neuroscience, 12, 371–384.

    Article  PubMed  Google Scholar 

  • Pascual-Leone, A., Gomez-Tortosa, E., Grafman, J., Alway, D., Nichelli, P., & Hallett, M. (1994). Induction of visual extinction by rapid-rate transcranial magnetic stimulation of parietal lobe. Neurology, 44, 494–498.

    PubMed  Google Scholar 

  • Paulus, W., Korinth, S., Wischer, S., & Tergau, F. (1999). Differential inhibition of chromatic and achromatic perception by transcranial magnetic stimulation of the human visual cortex. Neuroreport, 10, 1245–1248.

    Article  PubMed  Google Scholar 

  • Potts, G. F., Gugino, L. D., Leventon, M. E., Grimson, W. E. L., Kikinis, R., & Cote, W., et al. (1998). Visual hemifield mapping using transcranial magnetic stimulation coregistered with cortical surfaces derived from magnetic resonance images. Journal of Clinical Neurophysiology, 15, 344–350.

    Article  PubMed  Google Scholar 

  • Raiguel, S. E., Lagae, L., Gulyas, B., & Orban, G. A. (1989). Response latencies of visual cells in macaque areas V1, V2 and V5. Brain Research, 493, 155–159.

    Article  PubMed  Google Scholar 

  • Ro, T., Breitmeyer, B., Burton, P., Singhal, N. S., & Lane, D. (2003). Feedback contributions to visual awareness in human occipital cortex. Current Biology, 13, 1038–1041.

    Article  PubMed  Google Scholar 

  • Sack, A. T., & Linden, D. E. J. (2003). Combining transcranial magnetic stimulation and functional imaging in cognitive brain research: Possibilities and limitations. Brain Research Reviews, 43, 41–56.

    Article  PubMed  Google Scholar 

  • Sakai, K., Ugawa, Y., Terao, Y., Hanajima, R., Furubayashi, T., & Kanazawa, I. (1997). Preferential activation of different I wave by transcranial magnetic stimulation with a figure-of-eight-shaped coil. Experimental Brain Research, 113, 24–32.

    Article  Google Scholar 

  • Schmolesky, M. T., Wang, Y. C., Hanes, D. P., Thompson, K. G., Leutgeb, S., & Schall, J. D., et al. (1998). Signal timing across the macaque visual system. Journal of Neurophysiology, 79, 3272–3278.

    PubMed  Google Scholar 

  • Stewart, L. M., Walsh, V., & Rothwell, J. C. (2001). Motor and phosphene thresholds: A transcranial magnetic stimulation correlation study. Neuropsychologia, 39, 415–419.

    Article  PubMed  Google Scholar 

  • Thielscher, A., & Kammer, T. (2002). Linking Physics with Physiology in TMS: A sphere field model to determine the cortical stimulation site in TMS. Neuroimage, 17, 1117–1130.

    Article  PubMed  Google Scholar 

  • Vanni, S., Tanskanen, T., Seppa, M., Uutela, K., & Hari, R. (2001). Coinciding early activation of the human primary visual cortex and anteromedial cuneus. Proceedings of the National Academy of Sciences of the United States of America, 98, 2776–2780.

    Article  PubMed  Google Scholar 

  • Walsh, V., & Pascual-Leone, A. (2003). Transcranial magnetic stimulation. A neurochronometrics of mind. Cambridge: MIT press.

    Google Scholar 

  • Walsh, V., Ellison, A., Battelli, L., & Cowey, A. (1998). Task-specific impairments and enhancements induced by magnetic stimulation of human visual area v5. Proceedings of the Royal Society of London Series B- Biological Sciences, 265, 537–543.

    Article  Google Scholar 

Download references

Acknowledgements

I’d like to thank Sandra Beck, Michael Herzog, Katrin Hille, Kuno Kirschfeld, Hans-Günther Nusseck, Klaas Puls, Johannes Rüter, Frank Scharnowski, and Michael Vorwerg for support and for many fruitful discussions.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Thomas Kammer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kammer, T. Masking visual stimuli by transcranial magnetic stimulation. Psychological Research 71, 659–666 (2007). https://doi.org/10.1007/s00426-006-0063-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00426-006-0063-5

Keywords

Navigation