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MaxiK channel and cell signalling

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Pflügers Archiv - European Journal of Physiology Aims and scope Submit manuscript

Abstract

The large-conductance Ca2+- and voltage-activated K+ (MaxiK, BK, BKCa, Slo1, KCa1.1) channel role in cell signalling is becoming apparent as we learn how the channel interacts with a multiplicity of proteins not only at the plasma membrane but also in intracellular organelles including the endoplasmic reticulum, nucleus, and mitochondria. In this review, we focus on the interactions of MaxiK channels with seven-transmembrane G protein-coupled receptors and discuss information suggesting that, the channel big C-terminus may act as the nucleus of signalling molecules including kinases relevant for cell death and survival. Increasing evidence indicates that the channel is able to associate with a variety of receptors including β-adrenergic receptors, G protein-coupled estrogen receptors, acetylcholine receptors, thromboxane A2 receptors, and angiotensin II receptors, which highlights the varied functions that the channel has (or may have) not only in regulating contraction/relaxation of muscle cells or neurotransmission in the brain but also in cell metabolism, proliferation, migration, and gene expression. In line with this view, MaxiK channels have been implicated in obesity and in brain, prostate, and mammary cancers. A better understanding on the molecular mechanisms underlying or triggered by MaxiK channel abnormalities like overexpression in certain cancers may lead to new therapeutics to prevent devastating diseases.

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Acknowledgments

This work was supported by NIH grants, HL107418 and HL096740 (LT, ES) and HL088640 (ES) and by the American Heart Association National Scientist Development Award 11SDG7230059 (HS). Kcnma1−/− was kindly provided by Dr. Andrea Meredith (University of Maryland School of Medicine).

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  1. Harpreet Singh

    Present address: Department of Pharmacology and Physiology, Drexel University College of Medicine, 245 N. 15th Street, Room # 8154, New College Building, Philadelphia, PA, 19102-1192, USA

Authors and Affiliations

  1. Department of Anesthesiology, Division of Molecular Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA

    Ligia Toro, Min Li, Zhu Zhang, Harpreet Singh, Yong Wu & Enrico Stefani

  2. Department of Molecular & Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA

    Ligia Toro

  3. Department of Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA

    Enrico Stefani

  4. Brain Research Institute and Cardiovascular Research Laboratory, University of California, Los Angeles, Los Angeles, CA, 90095, USA

    Ligia Toro & Enrico Stefani

  5. Department of Anesthesiology, UCLA School of Medicine, BH-509A CHS, Box 957115, Los Angeles, CA, 90095-7115, USA

    Ligia Toro

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  1. Ligia Toro
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Correspondence to Ligia Toro.

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Toro, L., Li, M., Zhang, Z. et al. MaxiK channel and cell signalling. Pflugers Arch - Eur J Physiol 466, 875–886 (2014). https://doi.org/10.1007/s00424-013-1359-0

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  • DOI: https://doi.org/10.1007/s00424-013-1359-0

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