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SOD1 overexpression in paraventricular nucleus improves post-infarct myocardial remodeling and ventricular function

  • Cardiovascular Physiology
  • Published:
Pflügers Archiv - European Journal of Physiology Aims and scope Submit manuscript

Abstracts

Excessive sympathetic activation contributes to the progression of chronic heart failure. Reactive oxygen species in paraventricular nucleus (PVN) play an important role in the enhanced sympathetic outflow. This study was designed to determine whether superoxide dismutase 1 (SOD1) overexpression in the PVN attenuated the sympathetic activation and cardiac dysfunction in rats after an episode of myocardial infarction (MI). Adenoviral vectors containing human SOD1 (Ad-SOD) or null adenoviral vectors (Ad-null) were immediately microinjected into the PVN of rats with coronary artery ligation or sham operation. At the eighth week, the SOD1 protein level and activity in the PVN increased while the superoxide anions in the PVN decreased in Ad-SOD rats. The SOD1 overexpression in the PVN prevented the increases in left ventricular end-diastolic pressure and volume, and the decreases in ejection fraction and peak velocities of contraction in MI rats. In addition, there was an attenuation of renal sympathetic nerve activity, cardiac sympathetic afferent reflex and plasma norepinephrine level in MI rats. Furthermore, the SOD1 overexpression in the PVN reduced cardiomyocyte size, collagen deposition and the TUNEL-positive cardiomyocytes in MI rats. These results indicate that the SOD1 overexpression in the PVN attenuates the excessive sympathetic activation, myocardial remodeling, cardiomyocyte apoptosis and ventricular dysfunction in MI rats.

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Acknowledgements

This work was supported by Chinese National Natural Science Fund (30670768 and 30870908).

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Authors and Affiliations

  1. Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, 210029, China

    Juan Gao, Ming-Kui Zhong, Zhi-Dan Fan, Ye-Bo Zhou, Feng Zhang, Xing-Ya Gao & Guo-Qing Zhu

  2. Jiangsu Province Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu, 210029, China

    Juan Gao, Zhi-Dan Fan, Ning Yuan, Feng Zhang & Guo-Qing Zhu

  3. Department of Physiology, Anhui Medical University, Hefei, Anhui, 230032, China

    Ming-Kui Zhong

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  1. Juan Gao
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  2. Ming-Kui Zhong
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Correspondence to Guo-Qing Zhu.

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J. Gao and M.-K. Zhong contributed equally to this work.

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Gao, J., Zhong, MK., Fan, ZD. et al. SOD1 overexpression in paraventricular nucleus improves post-infarct myocardial remodeling and ventricular function. Pflugers Arch - Eur J Physiol 463, 297–307 (2012). https://doi.org/10.1007/s00424-011-1036-0

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  • DOI: https://doi.org/10.1007/s00424-011-1036-0

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