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TRP channels and mechanosensory transduction: insights into the arterial myogenic response

  • Ion Channels
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Abstract

Mechano-gated ion channels are implicated in a variety of key physiological functions ranging from touch sensitivity to arterial pressure regulation. Seminal work in prokaryotes and invertebrates provided strong evidence for the role of specific ion channels in volume regulation, touch sensitivity, or hearing, specifically the mechanosensitive channel subunits of large and small conductances (MscL and MscS), the mechanosensory channel subunits (MEC) and the transient receptor potential channel subunits (TRP). In mammals, recent studies further indicate that members of the TRP channel family may also be considered as possible candidate mechanosensors responding to either tension, flow, or changes in cell volume. However, contradictory results have challenged whether these TRP channels, including TRPC1 and TRPC6, are directly activated by mechanical stimulation. In the present review, we will focus on the mechanosensory function of TRP channels, discuss whether a direct or indirect mechanism is at play, and focus on the proposed role for these channels in the arterial myogenic response to changes in intraluminal pressure.

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Acknowledgments

We are grateful to the ANR 2005 Cardiovasculaire-obésité-diabète, to the Association for Information and Research on Genetic Kidney Disease France, to the Fondation del Duca, to the Fondation de France, to the Fondation de la Recherche Médicale, to EEC Marie-Curie fellowships, to the Fondation de Recherche sur l’Hypertension Artérielle, to AFM, to INSERM, and to CNRS for support and Human Frontiers Science Program (HFSP Research Grant Ref. RGP 32/2004 BN and a long-term fellowship Ref. LT00555 to Dr. Sharif-Naeini), the Belgian Federal Government, the Flemish Government, the Onderzoeksraad KU Leuven (GOA 2004/07, F.W.O. G. 0136.00; F.W.O. G.0172.03, Interuniversity Poles of Attraction Program, Prime Ministers Office IUAP Nr.3P4/23, Excellentiefinanciering EF/95/010) to BN.

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  1. Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR6097, 660 route des Lucioles, Sophia Antipolis, 06560, France

    Reza Sharif-Naeini, Alexandra Dedman, Joost H. A. Folgering, Fabrice Duprat, Amanda Patel & Eric Honoré

  2. KU Leuven, Department Mol Cell Biology, Laboratory Ion Channel Research, Campus Gasthuisberg, O&N 1, Herestraat 49-Bus 802, 3000, Leuven, Belgium

    Bernd Nilius

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  3. Joost H. A. Folgering
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  4. Fabrice Duprat
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  5. Amanda Patel
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  6. Bernd Nilius
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  7. Eric Honoré
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Correspondence to Eric Honoré.

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Sharif-Naeini, R., Dedman, A., Folgering, J.H.A. et al. TRP channels and mechanosensory transduction: insights into the arterial myogenic response. Pflugers Arch - Eur J Physiol 456, 529–540 (2008). https://doi.org/10.1007/s00424-007-0432-y

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  • DOI: https://doi.org/10.1007/s00424-007-0432-y

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