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Incidence and risk factor for infection of totally implantable venous access port

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Abstract

Background

Totally implantable venous access ports (TIVAP) have been widely used in cancer patients for many years. The early infection (within 30 days after TIVAP implantation) rate of TIVAP accounts for about one-third of all TIVAP infections, and early infection often causes port removal and affects subsequent cancer treatment. This study investigated the incidence and risk factors for early and late infection after TIVAP implantation.

Methods

From January 2013 to December 2018, all adult cancer patients who received TIVAP implantation in Taipei Medical University Shuang-Ho Hospital were reviewed. We evaluated the incidence of TIVAP-related infection, patient characteristics, and bacteriologic data. Univariable analysis and multiple logistic regression analysis were used to evaluate the risk factors of TIVAP-related infection.

Results

A total of 3001 TIVAPs were implanted in 2897 patients, and the median follow-up time was 424 days (range: 1–2492 days), achieving a combined total of 1,648,731 catheter days. Thirty-one patients (1.0%) had early infection and 167 (5.6%) patients had late infection. In multivariate analysis, TIVAP combined with other surgeries (p = 0.03) and inpatient setting (p < 0.001) was the risk factor of early infection, and TIVAP combined with other surgeries (p = 0.007), hematological cancer (p = 0.03), and inpatient setting (p < 0.001) was the risk factor of late infection.

Conclusion

Inpatient TIVAP implantation and TIVAP implantation combined with other surgeries are associated with high rates of TIVAP-related early and late infections.

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Data availability

The data that support the findings of this study are available from the corresponding author, Tung-Cheng Chang, upon reasonable request.

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Author information

Authors and Affiliations

  1. Division of Colorectal Surgery, Department of Surgery, Taipei Medical University Shuang-Ho Hospital, Number 291, Zhongzheng Road, Zhonghe District, Taipei City, 235, Taiwan

    Tung-Cheng Chang, Min-Hsuan Yen & Kee-Thai Kiu

  2. Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

    Tung-Cheng Chang

Authors
  1. Tung-Cheng Chang
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  2. Min-Hsuan Yen
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  3. Kee-Thai Kiu
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Contributions

Conception and design: Min-Hsuan Yen and Tung-Cheng Chang. Acquisition of data: Min-Hsuan Yen and Tung-Cheng Chang. Analysis and interpretation data: Min-Hsuan Yen, Kee-Thai Kiu and Tung-Cheng Chang. Writing, review, and revision of the manuscript: Tung-Cheng Chang.

Corresponding author

Correspondence to Tung-Cheng Chang.

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Ethics approval

This study was approved by the ethics committee of the Taipei Medical University (approval number: N201801072) and performed according to the declaration of Helsinki of 1964 and its later amendments or comparable ethical standards.

Informed consent

Informed consent was not applicable due to the retrospective nature of this study.

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The authors declare no competing of interests.

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Chang, TC., Yen, MH. & Kiu, KT. Incidence and risk factor for infection of totally implantable venous access port. Langenbecks Arch Surg 407, 343–351 (2022). https://doi.org/10.1007/s00423-021-02328-0

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  • DOI: https://doi.org/10.1007/s00423-021-02328-0

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