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Clinicopathologic analysis of surgically proven intraductal papillary mucinous neoplasms of the pancreas in SNUH: a 15-year experience at a single academic institution

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Abstract

Purpose

The clinical importance of intraductal papillary mucinous neoplasm of the pancreas (IPMN) has been increasing with a large number of newly diagnosed IPMN. This study was designed to explore the characteristics of resected IPMN and to determine the predictive factors for malignant and invasive IPMN.

Methods

Retrospective review of a prospectively collected database was performed on 187 consecutive patients following IPMN surgery between 1994 and 2008 at a tertiary institute. The main duct type IPMN was radiologically defined as main pancreatic duct dilation >5 mm rather than previously defined ≥10 mm.

Results

The morphologic types of IPMN included 28 main duct (IPMN-M, 15.0%), 118 branch duct (IPMN-Br, 63.1%), and 41 mixed (IPMN-Mixed, 21.9%) IPMNs. There were 23 patients with adenoma, 106 borderline atypia, 15 carcinoma in situ, and 43 invasive carcinoma. Sixty-nine extrapancreatic malignancies were diagnosed in 61 (32.6%) patients. Based on multivariate analysis, IPMN-M was statistically significant predictor of malignancy/invasiveness (p = 0.013/p = 0.028). In patients with IPMN-Br, the presence of mural nodule was a predictive factor for malignancy/invasiveness (p = 0.005/p = 0.002). In patients with IPMN-Mixed, mural nodule (p = 0.038/p = 0.047) and wall thickening (>2 mm, p = 0.015/p = 0.046) were risk factor for malignancy/invasiveness and elevated CA19-9 (p = 0.046) for invasiveness.

Conclusions

The main pancreatic duct diameter (>5 mm) is a significant predictor for malignancy and invasiveness. Therefore, IPMN patients with main pancreatic duct dilatation (>5 mm) should be considered surgical resection. Mural nodule is the indicator of surgery in IPMN-Br and IPMN-Mixed. In case of IPMN-Mixed with wall thickening or elevated serum CA19-9, surgical resection is recommended.

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Acknowledgments

Supported in part by a grant from the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (Grant No. 0820030).

Conflicts of Interest

None.

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Authors and Affiliations

  1. Department of Surgery, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-744, South Korea

    Dae Wook Hwang, Jin-Young Jang, Seung Eun Lee, Chang-Sup Lim, Kuhn Uk Lee & Sun-Whe Kim

  2. Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea

    Jin-Young Jang & Sun-Whe Kim

Authors
  1. Dae Wook Hwang
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  2. Jin-Young Jang
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  3. Seung Eun Lee
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  4. Chang-Sup Lim
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  5. Kuhn Uk Lee
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  6. Sun-Whe Kim
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Corresponding author

Correspondence to Sun-Whe Kim.

Additional information

Dae Wook Hwang and Jin-Young Jang are contributed equally to this study.

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Hwang, D.W., Jang, JY., Lee, S.E. et al. Clinicopathologic analysis of surgically proven intraductal papillary mucinous neoplasms of the pancreas in SNUH: a 15-year experience at a single academic institution. Langenbecks Arch Surg 397, 93–102 (2012). https://doi.org/10.1007/s00423-010-0674-6

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  • DOI: https://doi.org/10.1007/s00423-010-0674-6

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