Abstract.
To study the use-dependent modification of activity in neural networks, we investigated the spike timing by simultaneously recording activity at multiple sites in a network of cultured cortical neurons. We used dynamical analysis to study the temporal structure of spike trains and the activity-dependent changes in the reliability and reproducibility of spike patterns evoked by a stimulus. We also used cross-correlation analysis to evaluate the interactions of neuron pairs. Our main conclusions are that even when no obvious change in spike numbers can be seen, use-dependent modification occurs, either enhancing or reducing in the reliability and reproducibility of spike trains evoked by a stimulus, and the fine temporal structure of stimulus-evoked spike trains and interactions between neurons are also modified by tetanic stimulation.
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Received: 25 February 1998 / Accepted in revised form: 24 August 1998
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Tateno, T., Jimbo, Y. Activity-dependent enhancement in the reliability of correlated spike timings in cultured cortical neurons. Biol Cybern 80, 45–55 (1999). https://doi.org/10.1007/s004220050503
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DOI: https://doi.org/10.1007/s004220050503