Abstract
Lung diffusing capacity (DLCO) is influenced by alveolar-capillary membrane conductance (D M) and pulmonary capillary blood volume (V C), both of which can be impaired in sedentary type 1 diabetes mellitus (T1DM) subjects due to hyperglycemia. We sought to determine if T1DM, and glycemic control, affected DLNO, DLCO, D M, V C and SaO2 during maximal exercise in aerobically fit T1DM subjects. We recruited 12 T1DM subjects and 18 non-diabetic subjects measuring DLNO, DLCO, D M, and V C along with SaO2 and cardiac output (Q) at peak exercise. The T1DM subjects had significantly lower DLCO/Q and D M/Q with no difference in Q, DLNO, DLCO, D M, or V C (DLCO/Q = 2.1 ± 0.4 vs. 1.7 ± 0.3, D M/Q = 2.8 ± 0.6 vs. 2.4 ± 0.5, non-diabetic and T1DM, p < 0.05). In addition, when considering all subjects there was a relationship between DLCO/Q and SaO2 at peak exercise (r = 0.46, p = 0.01). Within the T1DM group, the optimal glycemic control group (HbA1c <7%, n = 6) had higher DLNO, DLCO, and D M/Q than the poor glycemic control subjects (HbA1c ≥7%, n = 6) at peak exercise (DLCO = 38.3 ± 8.0 vs. 28.5 ± 6.9 ml/min/mmHg, DLNO = 120.3 ± 24.3 vs. 89.1 ± 21.0 ml/min/mmHg, D M/Q = 3.8 ± 0.8 vs. 2.7 ± 0.2, optimal vs. poor control, p < 0.05). There was a negative correlation between HbA1c with DLCO, D M and D M/Q at peak exercise (DLCO: r = −0.70, p = 0.01; D M: r = −0.70, p = 0.01; D M/Q: r = −0.68, p = 0.02). These results demonstrate that there is a reduction in lung diffusing capacity in aerobically fit athletes with T1DM at peak exercise, but suggests that maintaining near-normoglycemia potentially averts lung diffusion impairments.
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Abbreviations
- HbA1c:
-
Glycosylated hemoglobin
- DLCO:
-
Diffusion of the lung for carbon monoxide
- DLNO:
-
Diffusion of the lung for nitric oxide
- D M :
-
Alveolar-capillary membrane conductance
- V C :
-
Pulmonary capillary blood volume
- Q:
-
Cardiac output
- DLCO/Q:
-
DLCO corrected for Q
- DM/Q:
-
DM corrected for Q
- SaO2 :
-
Peripheral oxygen saturation
- MTT:
-
Mean transit time
- FVC:
-
Forced vital capacity
- FEF25–75 :
-
Forced expiratory flow at 27–75% of forced vital capacity
- FEF50 :
-
Expiratory flow at 50% of forced vital capacity
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Communicated by Susan Ward.
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Wheatley, C.M., Baldi, J.C., Cassuto, N.A. et al. Glycemic control influences lung membrane diffusion and oxygen saturation in exercise-trained subjects with type 1 diabetes. Eur J Appl Physiol 111, 567–578 (2011). https://doi.org/10.1007/s00421-010-1663-8
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DOI: https://doi.org/10.1007/s00421-010-1663-8