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Foveal Abnormality associated with epiretinal Tissue of medium reflectivity and Increased blue-light fundus Autofluorescence Signal (FATIAS)

  • Retinal Disorders
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Abstract

Purpose

To describe a distinct vitreomacular interface disorder (VMID) termed Foveal Abnormality associated with epiretinal Tissue of medium reflectivity and Increased blue-light fundus Autofluorescence Signal (FATIAS).

Methods

A case series including forty-seven eyes of 47 patients. The included eyes must present an irregular foveal contour on optical coherence tomography (OCT) and a pathologically increased autofluorescent signal at the fovea on blue-light fundus autofluorescence (B-FAF). Main outcome measures were morphologic characteristics of the lesions, logarithm of minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA), and central foveal thickness (CFT).

Results

The following two types of FATIAS were identified: (1) the step type characterized by an asymmetric contour of the foveal pit and by a tissue of medium reflectivity on the foveal surface and (2) the rail type characterized by a shallow foveal pit and a rail of tissue of medium reflectivity on the foveal surface. The outer retinal bands were continuous in all cases. Both types presented with an area of increased B-FAF signal, usually bilobed in the step type and round and centered on the foveal pit in the rail type. LogMAR BCVA was 0.09 ± 0.1 and 0.1 ± 0.1 (P = 0.91), and CFT was 197.8 ± 9.7 and 202.2 ± 13.2 (P = 0.19) in the step and in the rail group, respectively.

Conclusions

We describe a distinct VMID named FATIAS. Two types of FATIAS may be appreciated with SD-OCT and B-FAF analyses, the step and the rail type. Both are characterized by abnormal foveal contour and autofluorescence signal.

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Authors and Affiliations

  1. Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Via Francesco De Sanctis 1, 86100, Campobasso, Italy

    Roberto dell’Omo & Ciro Costagliola

  2. Eye Clinic, Polytechnic University of Marche, Via Conca 71, 60121, Ancona, Italy

    Serena De Turris

  3. Department of Translational Surgery and Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy

    Gianni Virgili

  4. Department of Ophthalmology, Ludwig-Maximilians-University, Mathildenstrasse 8, 80336, Munich, Germany

    Ricarda G. Schumann

  5. Department of Biomedical and Clinical Science “Luigi Sacco,” Sacco Hospital, University of Milan, Via Andrea Verga 8, 20144, Milan, Italy

    Matteo Cereda, Isabella D’Agostino & Ferdinando Bottoni

  6. Eye Clinic “Villa Maria”, Viale Principe di Piemonte 4, 86100, Campobasso, Italy

    Ermanno dell’Omo

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  1. Roberto dell’Omo
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Correspondence to Roberto dell’Omo.

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Conflict of interests

R. dell’Omo declares that he has no conflict of interest; S. De Turris declares that she has no conflict of interest; C. Costagliola declares that he has no conflict of interest; G. Virgili declares that he has no conflict of interest; R.G. Schumann declares that she has no conflict of interest; M. Cereda declares that he is a consultant for Bayer; I. D’Agostino declares that she has no conflict of interest; E. dell’Omo declares that he has no conflict of interest; F. Bottoni declares that he is a consultant for Bayer, Novartis, and Alcon.

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dell’Omo, R., De Turris, S., Costagliola, C. et al. Foveal Abnormality associated with epiretinal Tissue of medium reflectivity and Increased blue-light fundus Autofluorescence Signal (FATIAS). Graefes Arch Clin Exp Ophthalmol 257, 2601–2612 (2019). https://doi.org/10.1007/s00417-019-04451-7

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  • DOI: https://doi.org/10.1007/s00417-019-04451-7

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