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Reduction of foveal bulges and other anatomical changes in fellow eyes of patients with unilateral idiopathic macular hole without vitreomacular pathologic changes

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To compare the foveal characteristics in fellow eyes (FE) of patients with unilateral idiopathic macular hole without vitreomacular pathologic changes with eyes of healthy controls.

Methods

Forty-seven FE and 52 eyes of 52 age- and sex-matched healthy controls were studied. Quantitative assessment of the dome-shaped appearance of the hyperreflective lines that represent external limiting membrane (ELM_bulge) and inner outer segment junctions (IS/OS_bulge) were made by optical coherence tomography (OCT) images. Inner retinal complex thickness (IRCT) was quantitatively assessed at 1000 and 2000 μm of the foveal center in nasal and temporal quadrants. Presence of alterations in the inner retinal outer layers and central foveal thickness (CFT) were also analyzed.

Results

Significantly lower ELM_bulge (p < 0.0001; Mann-Whitney test) and IS/OS_bulge (p < 0.001; student t test) and higher cases with COST alterations, expressed as a diffuse line (p < 0.006; Chi2 test) were found in FE than control eyes. IRCT were significantly reduced in FE at all the studied locations when comparing to control eyes (p < 0.05; student t test), maintaining anatomical proportionality among locations.

Conclusion

FE without pathologic vitreomacular interactions seems to present some central cone alterations that may be related to other causes than vitreomacular traction.

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Author information

Authors and Affiliations

  1. Department of Opthalmology, Hospital de Terrassa-Consorci Sanitari de Terrassa, Ctra Torrebonica s/n. Terrassa, 08227, Barcelona, Spain

    Barbara Delas

  2. Centro de Oftalmología Barraquer, Barcelona, Spain

    Gemma Julio, Álvaro Fernández-Vega & Jeroni Nadal

  3. Optics and Optometry Department, Universitat Politècnica de Catalunya-Barcelona Tech, Barcelona, Spain

    Gemma Julio

  4. Department of Surgery and Hospital Clinic de Barcelona (IDIBAPS), School of Medicine, Universitat de Barcelona, Barcelona, Spain

    Ricardo P. Casaroli-Marano

Authors
  1. Barbara Delas
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  2. Gemma Julio
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  3. Álvaro Fernández-Vega
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  4. Ricardo P. Casaroli-Marano
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  5. Jeroni Nadal
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Correspondence to Barbara Delas.

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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Delas, B., Julio, G., Fernández-Vega, Á. et al. Reduction of foveal bulges and other anatomical changes in fellow eyes of patients with unilateral idiopathic macular hole without vitreomacular pathologic changes. Graefes Arch Clin Exp Ophthalmol 255, 2141–2146 (2017). https://doi.org/10.1007/s00417-017-3765-z

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  • DOI: https://doi.org/10.1007/s00417-017-3765-z

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