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Outer photoreceptor layer thickness mapping in normal eyes and eyes with various macular diseases using spectral domain optical coherence tomography: A pilot study

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Background

To obtain a de novo map of outer photoreceptor layer (OPRL) thickness using a semiautomatic segmentation method for commercial spectral-domain optical coherence tomography (SD-OCT) and analyze the features of the resulting OPRL map in normal eyes and eyes with various inactive macular diseases.

Methods

Forty normal eyes and 50 eyes with various inactive macular diseases such as resolved central serous chorioretinopathy (20 eyes), surgically-repaired macular hole (10 eyes), epiretinal membrane (10 eyes), and reattached rhegmatogenous retinal detachment (10 eyes) were screened. All subjects underwent a 12 radial scan protocol in SD-OCT. The segmentation lines defining the OPRL were modified using built-in software. The diseased eyes were subdivided into two groups (good vision, or intermediate to poor vision) based on a visual acuity better or worse than 20/40. The map of the OPRL thickness was obtained automatically by the embedded software and was presented as the Early Treatment Diabetic Retinopathy Study (ETDRS) style.

Results

The mean OPRL thickness in normal eyes in all subfields was 40.37 ± 4.35 μm. The central subfield area showed the greatest mean OPRL thickness in normal eyes. The mean OPRL thickness of diseased eyes with good vision in the central subfield was greater than that of eyes with intermediate to poor vision. The OPRL thickness map showed various patterns according to the type of macular diseases.

Conclusions

We suggest that our semiautomated segmentation method using a 12 radial scan protocol is simple, fast, and suitable for producing a reliable OPRL map with ETDRS. This quantitative data could be useful in clinical practice or research of various macular diseases.

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Acknowledgments

This study adhered to the ethical standards in the Declaration of Helsinki, and was approved by the Institutional Review Board of Hanyang University Medical Center, Seoul, Korea.

Funding/Support

This work was supported by the research fund of Hanyang University (HY-2011-MC).

Financial disclosure

Dr. Lee is a consultant for Nidek, Gamagori, Japan.

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Authors and Affiliations

  1. Department of Ophthalmology, College of Medicine, Hanyang University, #17 Seongdong-gu, Haengdang-dong, Seoul, 133-792, Republic of Korea

    Yong Un Shin, Hee Yoon Cho & Byung Ro Lee

Authors
  1. Yong Un Shin
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  2. Hee Yoon Cho
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  3. Byung Ro Lee
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Corresponding author

Correspondence to Byung Ro Lee.

Additional information

Yong Un Shin and Hee Yoon Cho contributed equally to this work.

Authors have full control of all primary data and they agree to allow the Graefes Archive for Clinical and Experimental Ophthalmology to review their data upon request

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Shin, Y.U., Cho, H.Y. & Lee, B.R. Outer photoreceptor layer thickness mapping in normal eyes and eyes with various macular diseases using spectral domain optical coherence tomography: A pilot study. Graefes Arch Clin Exp Ophthalmol 251, 2529–2537 (2013). https://doi.org/10.1007/s00417-013-2352-1

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  • DOI: https://doi.org/10.1007/s00417-013-2352-1

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