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Effect of 1-year lutein supplementation on macular pigment optical density and visual function

  • Medical Ophthalmology
  • Published:
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Abstract

Background

Although it is known that antioxidants including lutein can affect macular pigment optical density (MPOD) and visual function, we still have much to learn about their effect. Our aim was to assess the 1-year changes in MPOD and visual function in response to supplementation containing lutein.

Methods

We prospectively measured the MPOD level of those who received a supplement containing 6 mg of lutein daily for 1 year. MPOD level was measured every 3 months by using autofluorescence spectrometry with the two-wavelength method. Other examinations, including contrast sensitivity and retinal sensitivity were also measured every 3 or 6 months. Stepwise regression analysis was performed to determine the factors that correlated with the changes observed in those examinations.

Results

Forty-three eyes of 43 Japanese subjects, including five normal eyes, five fellow eyes with central serous chorioretinopathy (CSC), and 33 fellow eyes with age-related macular degeneration (AMD) were enrolled. The higher baseline MPOD level was correlated with the eye with a clear intraocular lens (IOL). Although no time-dependent changes in the MPOD level were obtained in any area, subjects without cardiovascular diseases showed higher increase in the MPOD level. We observed significant increases in the contrast sensitivity at 1 year (p = 0.0124) and in the retinal sensitivity at 6 months (p < 0.0001) and 1 year (p < 0.0001). Stepwise regression analysis showed that nonsmokers had increased contrast sensitivity (p = 0.0173), and the fellow eye of those with CSC had less of an increase in retinal sensitivity (p = 0.0491).

Conclusions

Daily supplementation with 6 mg of lutein did not affect the MPOD level for 1 year, suggesting that 6 mg of lutein may be insufficient to increase the MPOD level. However, supplementation seems to improve visual functions such as contrast sensitivity and retinal sensitivity.

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Authors and Affiliations

  1. Department of Ophthalmology, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Yuzuru Sasamoto, Fumi Gomi, Miki Sawa, Motokazu Tsujikawa & Kohji Nishida

Authors
  1. Yuzuru Sasamoto
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  2. Fumi Gomi
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  3. Miki Sawa
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  4. Motokazu Tsujikawa
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  5. Kohji Nishida
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Corresponding author

Correspondence to Fumi Gomi.

Additional information

This clinical trial was registered at “http://www.umin.ac.jp” with study number of UMIN000001320 and was supported in part by Grants in Aid for Scientific Research from Japan Society for the Promotion of Science, Tokyo, Japan (No.22591942). Bausch & Lomb Japan, Ltd., Tokyo, Japan, also provided partial funding for this study. The authors have full control of all primary data and agree to allow Graefes Archive for Clinical and Experimental Ophthalmology to review this data upon request

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Sasamoto, Y., Gomi, F., Sawa, M. et al. Effect of 1-year lutein supplementation on macular pigment optical density and visual function. Graefes Arch Clin Exp Ophthalmol 249, 1847–1854 (2011). https://doi.org/10.1007/s00417-011-1780-z

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  • DOI: https://doi.org/10.1007/s00417-011-1780-z

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