Abstract
Purpose
Measurement of macular pigment optical density (MPOD) can be conducted to assist in the diagnosis of multiple fundus diseases.
Methods
Fifty-four subjects with high myopia were prospectively recruited for a 3-month clinical trial. Detailed ophthalmologic examinations and MPOD measurements were performed. The subjects in each high myopia category group were randomly subdivided into 5 intervention groups, including a low-dose Lycium barbarum group (10 g Lycium barbarum, containing 10 mg of zeaxanthin and 1 mg of lutein), low-dose control group (1 mg of lutein), high-dose Lycium barbarum group (20 g of Lycium barbarum, containing 20 mg of zeaxanthin and 2 mg lutein), high-dose control group (2 mg of lutein), and a blank control group. Differences in the MPODs among the high myopia groups were calculated with Welch two-sample t tests. A linear mixed-effects model was constructed and Pearson’s correlation analysis was performed to determine correlations between MPOD and other factors. The MPOD values at baseline and the 3-month follow-up were compared with the Mann–Whitney test.
Results
The category 1 group had a significantly higher MPOD than the category 2 (P = 0.02) and category 3 groups (P < 0.001). The category 2 group had a significantly higher MPOD than the category 3 group (P < 0.001). The MPOD significantly decreased with increasing axial length (AL) and decreasing best-corrected visual acuity (BCVA) in the category 1–3 groups and with increasing age and increasing intraocular pressure (IOP) in the category 2–3 groups. The MPOD was significantly higher in the group who received high-dose zeaxanthin from Lycium barbarum than in the group who received high-dose lutein at 3 months (P = 0.0403), while no significant difference was identified between the low-dose zeaxanthin group and low-dose lutein group (P = 0.1117).
Conclusions
The MPOD was negatively correlated with the category of high myopia. Supplementation of zeaxanthin from Lycium barbarum is beneficial in preventing the loss of macular pigment of high myopia patients.
Trial registration
Trial registration number and date of registration: ChiCTR2100046748.
Similar content being viewed by others
Data availability
Not applicable.
Code availability
Not applicable.
Change history
16 March 2022
A Correction to this paper has been published: https://doi.org/10.1007/s00417-022-05622-9
References
Jonas JB, Panda-Jonas S (2019) Epidemiology and anatomy of myopia. Ophthalmologe 116:499–508
Ohno-Matsui K, Kawasaki R, Jonas JB, Cheung CM, Saw SM, Verhoeven VJ, Klaver CC, Moriyama M, Shinohara K, Kawasaki Y, Yamazaki M, Meuer S, Ishibashi T, Yasuda M, Yamashita H, Sugano A, Wang JJ, Mitchell P, Wong TY, META-analysis for Pathologic Myopia (META-PM) Study Group (2015) International photographic classification and grading system for myopic maculopathy. Am J Ophthalmol 159: 877-883
Fang Y, Yokoi T, Nagaoka N, Shinohara K, Onishi Y, Ishida T, Yoshida T, Xu X, Jonas JB, Ohno-Matsui K (2018) Progression of myopic maculopathy during 18-year follow-up. Ophthalmology 125:863–877
Chan NS, Teo K, Cheung CM (2016) Epidemiology and diagnosis of myopic choroidal neovascularization in Asia. Eye Contact Lens 42:48–55
Wong TY, Ferreira A, Hughes R, Carter G, Mitchell P (2014) Epidemiology and disease burden of pathologic myopia and myopic choroidal neovascularization: an evidence-based systematic review. Am J Ophthalmol 157:9–25
Morgan IG, Ohno-Matsui K, Saw SM (2012) Myopia Lancet 379:1739–1748
Lin C, Li SM, Ohno-Matsui K, Wang BS, Fang YX, Cao K, Gao LQ, Hao J, Zhang Y, Wu J, Wang NL, Handan Eye Study Group (2018) Five-year incidence and progression of myopic maculopathy in a rural Chinese adult population: the Handan Eye Study. Ophthalmic Physiol Opt 38: 337-345
Ohno-Matsui K, Lai TY, Lai CC, Cheung CM (2016) Updates of pathologic myopia. Prog Retin Eye Res 52:156–187
Wiegand RD, Giusto NM, Rapp LM, Anderson RE (1983) Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina. Invest Ophthalmol Vis Sci 24:1433–1435
Snodderly DM, Auran JD, Delori FC (1984) The macular pigment. II. Spatial distribution in primate retinas. Invest Ophthalmol Vis Sci 25:674–685
Snodderly DM, Brown PK, Delori FC, Auran JD (1984) The macular pigment. I. Absorbance spectra, localization, and discrimination from other yellow pigments in primate retinas. Invest Ophthalmol Vis Sci 25:660–673
Mares JA, LaRowe TL, Snodderly DM, Moeller SM, Gruber MJ, Klein ML, Wooten BR, Johnson EJ, Chappell RJ, CAREDS Macular Pigment Study Group and Investigators (2006) Predictors of optical density of lutein and zeaxanthin in retinas of older women in the Carotenoids in Age-Related Eye Disease Study, an ancillary study of the Women’s Health Initiative. Am J Clin Nutr 84: 1107-1122
Wald G (1945) Human vision and the spectrum. Science 101:653–658
Bartlett H, Howells O, Eperjesi F (2010) The role of macular pigment assessment in clinical practice: a review. Clin Exp Optom 93:300–308
Sommerburg O, Keunen JE, Bird AC, van Kuijk FJ (1998) Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes. Br J Ophthalmol 82:907–910
Ciulla TA, Curran-Celantano J, Cooper DA, Hammond BR Jr, Danis RP, Pratt LM, Riccardi KA, Filloon TG (2001) Macular pigment optical density in a Midwestern sample. Ophthalmology 108:730–737
Bovier ER, Hammond BR (2015) A randomized placebo-controlled study on the effects of lutein and zeaxanthin on visual processing speed in young healthy subjects. Arch Biochem Biophys 572:54–57
Stringham JM, Stringham NT (2016) Serum and retinal responses to three different doses of macular carotenoids over 12 weeks of supplementation. Exp Eye Res 151:1–8
Tanito M, Obana A, Gohto Y, Okazaki S, Gellermann W, Ohira A (2012) Macular pigment density changes in Japanese individuals supplemented with lutein or zeaxanthin: quantification via resonance Raman spectrophotometry and autofluorescence imaging. Jpn J Ophthalmol 56:488–496
Hong IH, Jung WH, Lee JH, Chang IB (2020) Macular pigment optical density in the Korean population: a cross sectional study. J Korean Med Sci 35: e30
Yu J, Johnson EJ, Shang F, Lim A, Zhou H, Cui L, Xu J, Snellingen T, Liu X, Wang N, Liu N (2012) Measurement of macular pigment optical density in a healthy Chinese population sample. Invest Ophthalmol Vis Sci 53:2106–2111
Hogg RE, Anderson RS, Stevenson MR, Zlatkova MB, Chakravarthy U (2007) In vivo macular pigment measurements: a comparison of resonance Raman spectroscopy and heterochromatic flicker photometry. Br J Ophthalmol 91:485–490
Moreland JD (2004) Macular pigment assessment by motion photometry. Arch Biochem Biophys 430:143–148
Obana A, Tanito M, Gohto Y, Gellermann W, Okazaki S, Ohira A (2011) Macular pigment changes in pseudophakic eyes quantified with resonance Raman spectroscopy. Ophthalmology 118:1852–1858
Tong N, Zhang W, Zhang Z, Gong Y, Wooten B, Wu X (2013) Inverse relationship between macular pigment optical density and axial length in Chinese subjects with myopia. Graefes Arch Clin Exp Ophthalmol 251:1495–1500
Liew SH, Gilbert CE, Spector TD, Mellerio J, Van Kuijk FJ, Beatty S, Fitzke F, Marshall J, Hammond CJ (2006) Central retinal thickness is positively correlated with macular pigment optical density. Exp Eye Res 82:915–920
Wang G, Qiu KL, Lu XH, Sun LX, Liao XJ, Chen HL, Zhang MZ (2011) The effect of myopia on retinal nerve fibre layer measurement: a comparative study of spectral-domain optical coherence tomography and scanning laser polarimetry. Br J Ophthalmol 95:255–260
Stringham JM, Hammond BR (2008) Macular pigment and visual performance under glare conditions. Optom Vis Sci 85:82–88
Bhosale P, Zhao DY, Bernstein PS (2007) HPLC measurement of ocular carotenoid levels in human donor eyes in the lutein supplementation era. Invest Ophthalmol Vis Sci 48:543–549
Nagai N, Izumi-Nagai K, Suzuki M, Shinoda H, Koto T, Uchida A, Mochimaru H, Tomita Y, Miyake S, Kobayashi S, Sasaki M, Tsubota K, Ozawa Y (2015) Association of macular pigment optical density with serum concentration of oxidized low-density lipoprotein in healthy adults. Retina 35:820–826
Liu R, Wang T, Zhang B, Qin L, Wu C, Li Q, Ma L (2014) Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration. Invest Ophthalmol Vis Sci 56:252–258
Vishwanathan R, Gendron CM, Goodrow-Kotyla EF, Wilson TA, Nicolosi RJ (2010) Increased consumption of dietary cholesterol, lutein, and zeaxanthin as egg yolks does not decrease serum concentrations and lipoprotein distribution of other carotenoids, retinol, and tocopherols. Nutr Res 30:747–755
Kirby ML, Beatty S, Loane E, Akkali MC, Connolly EE, Stack J, Nolan JM (2010) A central dip in the macular pigment spatial profile is associated with age and smoking. Invest Ophthalmol Vis Sci 51:6722–6728
Loane E, Nolan JM, Beatty S (2010) The respective relationships between lipoprotein profile, macular pigment optical density, and serum concentrations of lutein and zeaxanthin. Invest Ophthalmol Vis Sci 51:5897–5905
Acknowledgements
We thank Dr. Yilin Li from Peking University for his advice on data analysis.
Funding
The study is supported by the funding from Beijing Traditional Chinese Medicine Technology Development Fund Project (JJ2018-50).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Ethics approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Beijing Tongren Hospital Ethics Committee (no. trecky2018-060).
Consent to participate
Informed consent was obtained from all individual participants included in the study.
Consent for publication
Patients signed informed consent regarding publishing their data.
Conflict of interest
The authors declare no competing interests.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
The original version of this article was revised. Article note is now added.
Rights and permissions
About this article
Cite this article
Zhang, Y., Hao, J., Cao, K. et al. Macular pigment optical density responses to different levels of zeaxanthin in patients with high myopia. Graefes Arch Clin Exp Ophthalmol 260, 2329–2337 (2022). https://doi.org/10.1007/s00417-021-05532-2
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00417-021-05532-2