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Subfoveal choroidal thickness in typical age-related macular degeneration and polypoidal choroidal vasculopathy

  • Retinal Disorders
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Abstract

Purpose

To investigate the subfoveal choroidal thickness in eyes with typical age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV), using enhanced depth imaging optical coherence tomography.

Methods

Retrospective observational case series of 44 eyes of 44 patients (12 females and 32 males) with typical AMD or PCV located in the subfoveal region. Cross-sectional images of the choroid of each of the involved eyes were obtained by a spectral-domain OCT. The choroidal thickness under the fovea was retrospectively studied.

Results

Of the 44 eyes involved in this study, 21 eyes were diagnosed as typical AMD and the other 23 eyes were diagnosed as PCV. The difference in subfoveal choroidal thickness between the eyes with typical AMD (245 μm) and those with PCV (293 μm) was statistically significant, even after adjusting for age, spherical equivalent, and gender distribution (P = 0.045). When compared to eyes with subfoveal choroidal thickness less than 300 μm, those with subfoveal choroidal thickness of 300 μm or more were 5.6 times more likely to have PCV (adjusted odds ratio 5.60, 95% confidence interval 1.30–24.0, P = 0.021).

Conclusions

The choroid under the fovea was thicker in eyes with PCV than those with typical AMD. This result suggests that the choroidal vascular lesion seen in PCV may not be just the choroidal neovascularization accompanied by saccular capillary dilations at the border, but may have a significant structural difference in the choroid compared to typical AMD.

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Authors and Affiliations

  1. Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602–0841, Japan

    Hideki Koizumi, Tetsuya Yamagishi, Taizo Yamazaki & Shigeru Kinoshita

  2. Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia

    Ryo Kawasaki

Authors
  1. Hideki Koizumi
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  2. Tetsuya Yamagishi
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  3. Taizo Yamazaki
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  4. Ryo Kawasaki
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  5. Shigeru Kinoshita
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Corresponding author

Correspondence to Hideki Koizumi.

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Grant information

This study was supported in part by Grant No.21890226 from Ministry of Education, Culture, Sports, Science and Technology–Japan (Dr. Koizumi).

Disclosures

The authors have no financial interests related to the material in the manuscript.

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Koizumi, H., Yamagishi, T., Yamazaki, T. et al. Subfoveal choroidal thickness in typical age-related macular degeneration and polypoidal choroidal vasculopathy. Graefes Arch Clin Exp Ophthalmol 249, 1123–1128 (2011). https://doi.org/10.1007/s00417-011-1620-1

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  • DOI: https://doi.org/10.1007/s00417-011-1620-1

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