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The sensorimotor network dysfunction in migraineurs without aura: a resting-state fMRI study

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Abstract

Migraine is a common recurrent neurological disorder combining nausea, vomiting, and hypersensitivities to visual, auditory, olfactory and somatosensory stimuli. However, the dysfunction of the sensorimotor network in migraineurs has not been well clarified. In the present study, we evaluated the dysfunction of the sensorimotor network in 30 migraineurs without aura and in 31 controls by combining regional homogeneity (ReHo), amplitudes of low-frequency fluctuation (ALFF) and degree centrality (DC) analysis methods based on resting-state fMRI. A seed-based functional connectivity (FC) analysis was used to investigate whether the dysfunctional areas within the sensorimotor network exhibited abnormal FC with other brain areas. Compared to the controls, the migraineurs without aura exhibited significantly smaller ReHo, ALFF and DC values in the primary somatosensory cortex (S1) and right premotor cortex (PMC). The migraineurs showed weaker FC between the S1 and brain areas within the pain intensity and spatial discrimination pathways and trigemino-thalamo-cortical nociceptive pathway. We proposed that the dysfunction of the S1 and PMC and the decreased FC between the S1 and brain areas in migraineurs without aura may disrupt the discrimination of sensory features of pain and affect nociception pathways, and would be involved in the dysfunctional mechanism in migraine.

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Acknowledgements

This research was supported by grants from the National Natural Science Foundation of China (Nos. 81571658 and 81201082 to X. X. Du), the National Natural Science Foundation of China (Nos. 81200941 to J. Su, 81271302 to J. R. Liu), projects from Shanghai Jiao Tong University Medical Engineering Cross Research Foundation (No. YG2014MS07 to J. Su), research innovation project from Shanghai municipal science and technology commission (No. 14JC1404300, to J. R. Liu), the “prevention and control of chronic diseases project” of Shanghai Hospital Development Center (No. SHDC12015310, to J. R. Liu), project from SHSMU-ION Research Center for Brain Disorders (No. 2015NKX006, to J. R. Liu), project from Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support (No. 20161422 to J. R. Liu), Clinical Research Project from Shanghai Jiao Tong University School of Medicine (No. DLY201614 to J. R. Liu), and Biomedicine Key program from Shanghai Municipal Science and Technology Commission (No. 16411953100 to J. R. Liu).

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Authors and Affiliations

  1. Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, 3663 North Zhong-Shan Road, Shanghai, 200062, People’s Republic of China

    Jilei Zhang, Mengxing Wang, Haifeng Lu, Hui Zhang, Jianqi Li & Xiaoxia Du

  2. Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, People’s Republic of China

    Jingjing Su, Ying Zhao, Qi-Ting Zhang, Qian Yao, Ge-Fei Li, Yi-Lan Wu, Yi-Sheng Liu, Feng-Di Liu, Mei-Ting Zhuang, Yan-Hui Shi, Tian-Yu Hou, Rong Zhao, Yuan Qiao & Jian-Ren Liu

  3. Clinical Research Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China

    Feng-Di Liu, Yan-Hui Shi, Rong Zhao, Yuan Qiao & Jian-Ren Liu

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  1. Jilei Zhang
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  2. Jingjing Su
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Correspondence to Jian-Ren Liu or Xiaoxia Du.

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Zhang, J., Su, J., Wang, M. et al. The sensorimotor network dysfunction in migraineurs without aura: a resting-state fMRI study. J Neurol 264, 654–663 (2017). https://doi.org/10.1007/s00415-017-8404-4

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  • DOI: https://doi.org/10.1007/s00415-017-8404-4

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