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Neurological update: emerging issues in gait disorders

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Abstract

Gait disorders represent a common and diverse challenge in Neurological practice. The literature on this field is expanding and is seeking to address mainstream clinical issues as well as a greater understanding of pathophysiological mechanisms. This update will introduce a range of these concepts.

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References

  1. Studenski S, Perera S, Patel K et al (2011) Gait speed and survival in older adults. JAMA 305(1):50–58

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  2. Visser H (1983) Gait and balance in senile dementia of Alzheimer’s type. Age Ageing 12(4):296–301

    Article  CAS  PubMed  Google Scholar 

  3. Cedervall Y, Halvorsen K, Aberg AC (2014) A longitudinal study of gait function and characteristics of gait disturbance in individuals with Alzheimer’s disease. Gait Posture 39(4):1022–1027

    Article  PubMed  Google Scholar 

  4. Allan LM, Ballard CG, Burn DJ, Kenny RA (2005) Prevalence and severity of gait disorders in Alzheimer’s and non-Alzheimer’s dementias. J Am Geriatr Soc 53(10):1681–1687

    Article  PubMed  Google Scholar 

  5. Ala TA, Frey WH 2nd (1995) Validation of the NINCDS-ADRDA criteria regarding gait in the clinical diagnosis of Alzheimer disease. A clinicopathologic study. Alzheimer Dis Assoc Disord 9(3):152–159

    Article  CAS  PubMed  Google Scholar 

  6. Verghese J, Lipton RB, Hall CB, Kuslansky G, Katz MJ, Buschke H (2002) Abnormality of gait as a predictor of non-Alzheimer’s dementia. N Engl J Med 347(22):1761–1768

    Article  PubMed  Google Scholar 

  7. Waite LM, Grayson DA, Piguet O, Creasey H, Bennett HP, Broe GA (2005) Gait slowing as a predictor of incident dementia: 6-year longitudinal data from the Sydney Older Persons Study. J Neurol Sci 229–230:89–93

    Article  PubMed  Google Scholar 

  8. Verghese J, Wang C, Lipton RB, Holtzer R, Xue X (2007) Quantitative gait dysfunction and risk of cognitive decline and dementia. J Neurol Neurosurg Psychiatry 78(9):929–935

    Article  PubMed Central  PubMed  Google Scholar 

  9. Verghese J, Wang C, Lipton RB, Holtzer R (2013) Motoric cognitive risk syndrome and the risk of dementia. J Gerontol A Biol Sci Med Sci 68(4):412–418

    Article  PubMed Central  PubMed  Google Scholar 

  10. Ebersbach G, Moreau C, Gandor F, Defebvre L, Devos D (2013) Clinical syndromes: Parkinsonian gait. Mov Disord 28(11):1552–1559

    Article  PubMed  Google Scholar 

  11. Postuma RB, Aarsland D, Barone P et al (2012) Identifying prodromal Parkinson’s disease: pre-motor disorders in Parkinson’s disease. Mov Disord 27(5):617–626

    Article  PubMed  Google Scholar 

  12. Iranzo A, Tolosa E, Gelpi E et al (2013) Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study. Lancet Neurol 12(5):443–453

    Article  PubMed  Google Scholar 

  13. Schenck CH, Boeve BF, Mahowald MW (2013) Delayed emergence of a parkinsonian disorder or dementia in 81 % of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. Sleep Med 14(8):744–748

    Article  PubMed  Google Scholar 

  14. Benninger DH, Michel J, Waldvogel D et al (2010) REM sleep behavior disorder is not linked to postural instability and gait dysfunction in Parkinson. Mov Disord 25(11):1597–1604

    Article  PubMed  Google Scholar 

  15. Bugalho P, Viana-Baptista M (2013) REM sleep behavior disorder and motor dysfunction in Parkinson’s disease—a longitudinal study. Parkinsonism Relat Disord 19(12):1084–1087

    Article  PubMed  Google Scholar 

  16. McDade EM, Boot BP, Christianson TJ et al (2013) Subtle gait changes in patients with REM sleep behavior disorder. Mov Disord 28(13):1847–1853

    Article  PubMed Central  PubMed  Google Scholar 

  17. Panyakaew P, Bhidayasiri R (2013) The spectrum of preclinical gait disorders in early Parkinson’s disease: subclinical gait abnormalities and compensatory mechanisms revealed with dual tasking. J Neural Transm (Vienna, Austria: 1996) 120(12):1665–1672

    Article  CAS  Google Scholar 

  18. Rochester L, Galna B, Lord S, Burn D (2014) The nature of dual-task interference during gait in incident Parkinson’s disease. Neuroscience 265:83–94

    Article  CAS  PubMed  Google Scholar 

  19. Lord S, Godfrey A, Galna B, Mhiripiri D, Burn D, Rochester L (2013) Ambulatory activity in incident Parkinson’s: more than meets the eye? J Neurol 260(12):2964–2972

    Article  PubMed  Google Scholar 

  20. Lewis SJG, Foltynie T, Blackwell AD, Robbins TW, Owen AM, Barker RA (2005) Heterogeneity of Parkinson’s disease in the early clinical stages using a data driven approach. J Neurol Neurosurg Psychiatry 76:343–348

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  21. Herman T, Rosenberg-Katz K, Jacob Y et al (2013) White matter hyperintensities in Parkinson’s disease: do they explain the disparity between the postural instability gait difficulty and tremor dominant subtypes? PLoS One 8(1):e55193

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  22. Rosenberg-Katz K, Herman T, Jacob Y, Giladi N, Hendler T, Hausdorff JM (2013) Gray matter atrophy distinguishes between Parkinson disease motor subtypes. Neurology 80(16):1476–1484

    Article  PubMed Central  PubMed  Google Scholar 

  23. Herman T, Weiss A, Brozgol M, Giladi N, Hausdorff JM (2014) Gait and balance in Parkinson’s disease subtypes: objective measures and classification considerations. J Neurol 261(12):2401–2410. doi:10.1007/s00415-014-7513-6

    Article  PubMed  Google Scholar 

  24. Gauthier S, Reisberg B, Zaudig M et al (2006) Mild cognitive impairment. Lancet 367(9518):1262–1270

    Article  PubMed  Google Scholar 

  25. Annweiler C, Beauchet O, Bartha R et al (2013) Motor cortex and gait in mild cognitive impairment: a magnetic resonance spectroscopy and volumetric imaging study. Brain 136(Pt 3):859–871

    Article  PubMed  Google Scholar 

  26. de Laat KF, Tuladhar AM, van Norden AG, Norris DG, Zwiers MP, de Leeuw FE (2011) Loss of white matter integrity is associated with gait disorders in cerebral small vessel disease. Brain 134(Pt 1):73–83

    Article  PubMed  Google Scholar 

  27. Nutt JG (2013) Higher-level gait disorders: an open frontier. Mov Disord 28(11):1560–1565

    Article  PubMed  Google Scholar 

  28. Demain A, Westby GW, Fernandez-Vidal S et al (2014) High-level gait and balance disorders in the elderly: a midbrain disease? J Neurol 261(1):196–206

    Article  PubMed Central  PubMed  Google Scholar 

  29. Williams-Gray CH, Foltynie T, Lewis SJG, Barker RA (2006) Cognitive deficits and psychosis in Parkinson’s disease: a review of pathophysiology and therapeutic options. CNS Drugs 20(6):477–505

    Article  CAS  PubMed  Google Scholar 

  30. Bohnen NI, Frey KA, Studenski S et al (2013) Gait speed in Parkinson disease correlates with cholinergic degeneration. Neurology 81(18):1611–1616

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  31. Rochester L, Yarnall AJ, Baker MR et al (2012) Cholinergic dysfunction contributes to gait disturbance in early Parkinson’s disease. Brain 135(Pt 9):2779–2788

    Article  PubMed Central  PubMed  Google Scholar 

  32. Bohnen NI, Frey KA, Studenski S et al (2014) Extra-nigral pathological conditions are common in Parkinson’s disease with freezing of gait: an in vivo positron emission tomography study. Mov Disord 29(9):1118–1124

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  33. Nieuwboer A, Giladi N (2013) Characterizing freezing of gait in Parkinson’s disease: models of an episodic phenomenon. Mov Disord 28(11):1509–1519

    Article  PubMed  Google Scholar 

  34. Kostic VS, Agosta F, Pievani M et al (2012) Pattern of brain tissue loss associated with freezing of gait in Parkinson disease. Neurology 78(6):409–416

    Article  CAS  PubMed  Google Scholar 

  35. Tessitore A, Amboni M, Cirillo G et al (2012) Regional gray matter atrophy in patients with Parkinson disease and freezing of gait. AJNR Am J Neuroradiol 33(9):1804–1809

    Article  CAS  PubMed  Google Scholar 

  36. Herman T, Rosenberg-Katz K, Jacob Y, Giladi N, Hausdorff JM (2014) Gray matter atrophy and freezing of gait in Parkinson’s disease: is the evidence black-on-white? Mov Disord 29(1):134–139

    Article  PubMed  Google Scholar 

  37. Rubino A, Assogna F, Piras F, Di Battista ME, Imperiale F, Chiapponi C, Spalletta G, Meco G (2014) Does a volume reduction of the parietal lobe contribute to freezing of gait in Parkinson’s disease? Parkinsonism Relat Disord 20(10):1101–1103. doi:10.1016/j.parkreldis.2014.07.002

    Article  PubMed  Google Scholar 

  38. Youn J, Cho JW, Lee WY, Kim GM, Kim ST, Kim HT (2012) Diffusion tensor imaging of freezing of gait in patients with white matter changes. Mov Disord 27(6):760–764

    Article  PubMed  Google Scholar 

  39. Fling BW, Cohen RG, Mancini M, Nutt JG, Fair DA, Horak FB (2013) Asymmetric pedunculopontine network connectivity in parkinsonian patients with freezing of gait. Brain 136(Pt 8):2405–2418

    Article  PubMed Central  PubMed  Google Scholar 

  40. Shine JM, Matar E, Ward PB et al (2013) Exploring the cortical and subcortical functional magnetic resonance imaging changes associated with freezing in Parkinson’s disease. Brain 136(Pt 4):1204–1215

    Article  PubMed  Google Scholar 

  41. Vercruysse S, Spildooren J, Heremans E, Wenderoth N, Swinnen SP, Vandenberghe W, Nieuwboer A (2014) The neural correlates of upper limb motor blocks in Parkinson’s disease and their relation to freezing of gait. Cereb Cortex 24(12):3154–3166. doi:10.1093/cercor/bht170

    Article  CAS  PubMed  Google Scholar 

  42. Shine JM, Matar E, Bolitho SJ et al (2013) Modeling freezing of gait in Parkinson’s disease with a virtual reality paradigm. Gait Posture 38(1):104–108

    Article  CAS  PubMed  Google Scholar 

  43. Shine JM, Matar E, Ward PB et al (2013) Freezing of gait in Parkinson’s disease is associated with functional decoupling between the cognitive control network and the basal ganglia. Brain 136(Pt 12):3671–3681

    Article  PubMed  Google Scholar 

  44. Shine JM, Handojoseno AM, Nguyen TN, Tran Y, Naismith SL, Nguyen H, Lewis SJ (2014) Abnormal patterns of theta frequency oscillations during the temporal evolution of freezing of gait in Parkinson’s disease. Clin Neurophysiol 125(3):569–576. doi:10.1016/j.clinph.2013.09.006

    Article  CAS  PubMed  Google Scholar 

  45. Handojoseno AM, Shine JM, Nguyen TN, Tran Y, Lewis SJ, Nguyen HT (2012) The detection of Freezing of Gait in Parkinson’s disease patients using EEG signals based on Wavelet decomposition. Conf Proc 2012:69–72

    Google Scholar 

  46. Lewis SJG, Barker RA (2009) A pathophysiological model of freezing of gait in Parkinson’s disease. Parkinsonism Relat Disord 15(5):333–338

    Article  PubMed  Google Scholar 

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Correspondence to Simon J. G. Lewis.

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Lewis, S.J.G. Neurological update: emerging issues in gait disorders. J Neurol 262, 1590–1595 (2015). https://doi.org/10.1007/s00415-015-7686-7

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  • DOI: https://doi.org/10.1007/s00415-015-7686-7

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