Skip to main content
Log in

Temporal evolution of sporadic Creutzfeldt–Jakob disease monitored by 3-Tesla MR spectroscopy

  • Letter to the Editors
  • Published:
Journal of Neurology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Zerr I, Kallenberg K, Summers DM, Romero C, Taratuto A, Heinemann U, Breithaupt M, Varges D, Meissner B, Ladogana A, Schuur M, Haik S, Collins SJ, Jansen GH, Stokin GB, Pimentel J, Hewer E, Collie D, Smith P, Roberts H, Brandel JP, van Duijn C, Pocchiari M, Begue C, Cras P, Will RG, Sanchez-Juan P (2009) Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease. Brain 132:2659–2668

    Article  PubMed  CAS  Google Scholar 

  2. Lodi R, Parchi P, Tonon C, Manners D, Capellari S, Strammiello R, Rinaldi R, Testa C, Malucelli E, Mostacci B, Rizzo G, Pierangeli G, Cortelli P, Montagna P, Barbiroli B (2009) Magnetic resonance diagnostic markers in clinically sporadic prion disease: a combined brain magnetic resonance imaging and spectroscopy study. Brain 132:2669–2679

    Article  PubMed  Google Scholar 

  3. Galanaud D, Haik S, Linguraru MG, Ranjeva JP, Faucheux B, Kaphan E, Ayache N, Chiras J, Cozzone P, Dormont D, Brandel JP (2010) Combined diffusion imaging and MR spectroscopy in the diagnosis of human prion diseases. Am J Neuroradiol 31:1311–1318

    Article  PubMed  Google Scholar 

  4. Soares DP, Law M (2009) Magnetic resonance spectroscopy of the brain: review of metabolites and clinical applications. Clin Radiol 64:12–21

    Article  PubMed  CAS  Google Scholar 

  5. World Health Organization (1998) Human transmissible spongiform encephalopathies. WHO Weekly Epidemiological Record 73:361–372

    Google Scholar 

  6. Fulbright RK, Kingsley PB, Guo X, Hoffmann C, Kahana E, Chapman JC, Prohovnik I (2006) The imaging appearance of Creutzfeldt-Jakob disease caused by the E200 K mutation. Magn Reson Imaging 24:1121–1129

    Article  PubMed  CAS  Google Scholar 

  7. Waldman AD, Cordery RJ, MacManus DG, Godbolt A, Collinge J, Rossor MN (2006) Regional brain metabolite abnormalities in inherited prion disease and asymptomatic gene carriers demonstrated in vivo by quantitative proton magnetic resonance spectroscopy. Neuroradiology 48:428–433

    Article  PubMed  CAS  Google Scholar 

  8. Haïk S, Galanaud D, Linguraru MG, Peoc’h K, Privat N, Faucheux BA, Ayache N, Hauw JJ, Dormont D, Brandel JP (2008) In vivo detection of thalamic gliosis: a pathoradiologic demonstration in familial fatal insomnia. Arch Neurol 65:545–549

    Article  PubMed  Google Scholar 

  9. Pellerin L, Magistretti PJ (1994) Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci USA 91:10625–10629

    Article  PubMed  CAS  Google Scholar 

  10. Kleene R, Loers G, Langer J, Frobert Y, Buck F, Schachner M (2007) Prion protein regulates glutamate-dependent lactate transport of astrocyte. J Neurosci 27:12331–12340

    Article  PubMed  CAS  Google Scholar 

  11. Awerbuch G, Peterson P, Sandyk R (1988) Elevated cerebrospinal fluid lactic acid levels in Creutzfeldt-Jakob disease. Int J Neurosci 42:1–5

    Article  PubMed  CAS  Google Scholar 

  12. Kitamoto T, Muramoto T, Hilbich C, Beyreuther K, Tateishi J (1991) N-terminal sequence of prion protein is also integrated into kuru plaques in patients with Gerstmann-Sträussler syndrome. Brain Res 545:319–321

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

We thank Tetsuyuki Kitamoto (Tohoku University, analyses of PRNP and pathology); Shuji Hashiguchi and Katsuhito Adachi (Tokushima Hospital, clinical care and the necropsy procedure); Katsuya Satoh (Nagasaki University, measurement of 14-3-3 protein); and Toshiaki Sano (The University of Tokushima, necropsy procedure). This work was supported by Grants-in-Aid from the Research Committee of Prion Disease and Slow Virus Infection, the Ministry of Health, Labour and Welfare of Japan.

Conflict of interest

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Koji Fujita.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fujita, K., Harada, M., Yuasa, T. et al. Temporal evolution of sporadic Creutzfeldt–Jakob disease monitored by 3-Tesla MR spectroscopy. J Neurol 258, 1368–1370 (2011). https://doi.org/10.1007/s00415-011-5939-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-011-5939-7

Keywords

Navigation