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Incidence of central nervous system involvement in chronic lymphocytic leukemia and outcome to treatment

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Abstract

Leptomeningeal involvement in patients with CLL is relatively rare and the prognosis is usually considered to be poor. The authors reviewed all CLL patients treated in a tertiary referral center to assess the incidence and outcome of leptomeningeal involvement (LI) in CLL. They found an incidence of 1–2% of LI. Most of the patients with LI had a longterm survival, despite failure to clear the cerebrospinal fluid from tumor cells.

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Authors and Affiliations

  1. Dept. of Neuro-Oncology, Daniel den Hoed Cancer Center, 5201, 3008AE, Rotterdam, The Netherlands

    M. C. J. Hanse & M. J. van den Bent

  2. Dept. of Hematology, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

    M. B. van’t Veer & K. van Lom

Authors
  1. M. C. J. Hanse
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  2. M. B. van’t Veer
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  3. K. van Lom
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  4. M. J. van den Bent
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Correspondence to M. J. van den Bent.

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Hanse, M.C.J., van’t Veer, M.B., van Lom, K. et al. Incidence of central nervous system involvement in chronic lymphocytic leukemia and outcome to treatment. J Neurol 255, 828–830 (2008). https://doi.org/10.1007/s00415-008-0710-4

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  • DOI: https://doi.org/10.1007/s00415-008-0710-4

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