Skip to main content
SpringerLink
Log in

Assessing Transient Pulmonary Injury Induced by Volatile Anesthetics by Increased Lung Uptake of Technetium-99m Hexamethylpropylene Amine Oxime

  • Published:
Lung Aims and scope Submit manuscript

Abstract

Volatile anesthetics such as halothane and isoflurane have long been thought to affect pulmonary function. The purpose of this study was to examine whether volatile anesthetics (halothane and isoflurane) can induce pulmonary vascular endothelium damage. Before surgery, 1 h after surgery, and 1 week after surgery, the degree of pulmonary vascular endothelium damage was represented as increased lung/liver uptake ratios (L/L ratio) and measured on technetium-99m hexamethylpropylene amine oxime (Tc-99m HMPAO) lung scan in 3 groups of the patients. Group 1 included 20 patients undergoing surgery and receiving volatile anesthesia with 1% halothane. Group 2 included 20 patients undergoing surgery and receiving volatile anesthesia with 1.5% isoflurane. Group 3 included 20 patients undergoing surgery with intravenous anesthesia drugs. No significant change of L/L ratio was found from before surgery, 1 h after surgery, to 1 week after surgery in group 3 patients. In groups 1 and 2 patients, significantly transient increased L/L ratio was found 1 h after surgery. We conclude that volatile anesthesia (halothane and isoflurane) can induce transient pulmonary vascular endothelium damage, represented as transiently increased L/L ratios on Tc-99m HMPAO lung scan.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. R Dueck I Young J Clausen P Wagner (1980) ArticleTitleAltered distribution of pulmonary ventilation and blood flow following induction of inhalational anesthesia. Anesthesiology 52 113–125 Occurrence Handle1:STN:280:Bi%2BC3cjktlw%3D Occurrence Handle6243450

    CAS  PubMed  Google Scholar 

  2. B Gunaydin Y Karadenizli A Babacan K Kaya M Unlu S Inanir A Mahli M Akcabay S Yardim (1997) ArticleTitlePulmonary microvascular injury following general anaesthesia with volatile anaesthetics-halothane and isoflurane: a comparative clinical and experimental study. Respir Med 91 351–360 Occurrence Handle1:STN:280:ByiH38jhtFw%3D Occurrence Handle9282238

    CAS  PubMed  Google Scholar 

  3. CM Shih YC Shiau JJ Wang ST Ho A Kao (2002) ArticleTitleIncreased lung uptake of technetium-99m hexamethylpropylene amine oxime in systemic lupus erythematosus. Respiration 69 143–147 Occurrence Handle10.1159/000056317 Occurrence Handle1:CAS:528:DC%2BD38XivVOqsro%3D Occurrence Handle11961428

    Article  CAS  PubMed  Google Scholar 

  4. K Suga H Uchisako K Nishigauchi K Shimizu N Kume N Yamada T Nakanishi (1994) ArticleTitleTechnetium-99m-HMPAO as a marker of chemical and irradiation lung injury: experimental and clinical investigations. J Nucl Med 35 1520–1527

    Google Scholar 

  5. SS Sun JF Hsieh SC Tsai YJ Ho CH Kao (2000) ArticleTitleTransient increase in alveolar epithelial permeability induced by volatile anaesthesia with isoflurane. Lung 178 129–135 Occurrence Handle10.1007/s004080000016 Occurrence Handle1:CAS:528:DC%2BD3cXlsFWju7o%3D Occurrence Handle10871431

    Article  CAS  PubMed  Google Scholar 

  6. IM Tocino (1990) Chest radiology and other imaging techniques. GW Cannon GA Zimmerman (Eds) The lung in rheumatic diseases. Marcel Dekker Inc. New York 81–116

    Google Scholar 

  7. JJ Touya J Rahimian DE Grubbs HF Corbus LR Bennett (1985) ArticleTitleA noninvasive procedure for in vivo assay of a lung amine endothelial receptor. J Nucl Med 26 1302–1307

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Anesthesia, Pain Clinic & Critical Care Medicine, China Medical College Hospital, Taichung, Taiwan

    C. -J. Hung

  2. Department of Nuclear Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan

    F. -Y. Liu & Y. -C. Shaiu

  3. Department of Medical Research, China Medical College Hospital, Taichung, Taiwan

    A. Kao & C. -C. Lee

  4. Department of Family Medicine, China Medical College Hospital, Taichung, Taiwan

    C. -C. Lin

Authors
  1. C. -J. Hung
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. -Y. Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Y. -C. Shaiu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Kao
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C. -C. Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. -C. Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. Kao.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hung, CJ., Liu, FY., Shaiu, YC. et al. Assessing Transient Pulmonary Injury Induced by Volatile Anesthetics by Increased Lung Uptake of Technetium-99m Hexamethylpropylene Amine Oxime . Lung 181, 1–7 (2003). https://doi.org/10.1007/s00408-002-0109-4

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00408-002-0109-4

Keywords

Search

Navigation