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Mismatch negativity at acute and post-acute phases of first-episode schizophrenia

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Abstract

The objective of this study was to evaluate the mismatch negativity (MMN) in patients with first-episode schizophrenia at acute and post-acute phases in order to determine the contribution of trait and/or state features to MMN disturbances in schizophrenia. Subject groups comprised 30 patients with first-episode schizophrenia at the acute phase and 34 healthy controls. Ten patients were neuroleptic-naive during testing at the acute phase. Twenty-one patients were retested at the post-acute phase when their symptoms improved. All patients were taking antipsychotic medication at the post-acute retest session. MMN amplitude of the patients at acute phase did not differ from controls. However, MMN amplitude at post-acute phase was reduced compared to both controls and acute phase. Similar results were obtained when the analyses were confined to neuroleptic-naive patients. The sensory memory functions indexed by MMN seem to be unaffected at the onset of schizophrenia but deteriorated during the post-acute illness phase. MMN reduction at the post-acute phase might be emerged from antipsychotic medication.

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Acknowledgements

This work was supported by the Research Fund of The University of Istanbul. Project numbers: 173/15012004 and UDP-826/19072006.

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Authors and Affiliations

  1. Department of Physiology, Istanbul Medical Faculty, University of Istanbul, 34093, Çapa-Istanbul, Turkey

    Müge Devrim-Üçok & H. Yasemin Keskin-Ergen

  2. Department of Psychiatry, Istanbul Medical Faculty, University of Istanbul, 34093, Çapa-Istanbul, Turkey

    Alp Üçok

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  1. Müge Devrim-Üçok
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Correspondence to Müge Devrim-Üçok.

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Devrim-Üçok, M., Keskin-Ergen, H.Y. & Üçok, A. Mismatch negativity at acute and post-acute phases of first-episode schizophrenia. Eur Arch Psychiatry Clin Neurosc 258, 179–185 (2008). https://doi.org/10.1007/s00406-007-0772-9

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