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The identification of induction chemo-sensitivity genes of laryngeal squamous cell carcinoma and their clinical utilization

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

To identify potential molecular markers for induction chemotherapy of Laryngeal squamous cell carcinoma (LSCC).

Methods

Differently expressed genes between chemo-sensitive group (seven cases) and chemo-insensitive (five cases) group after induction chemotherapy by TPF were identified by microarrays. Bayes network and Random forest analyses were employed to identify core genes for induction chemotherapy. The diagnostic value of these core genes was also evaluated by ROC analysis.

Results

Six genes (SPP1, FOLR3, KYNU, LOC653219, ADH7 and XAGE1A) are highly expressed, while seven gene (CADM1, NDUFA4L2, CCND2, RARRES3, ERAP2, LYD6 and CNTNAP2) present significantly low expression. Among these genes, genes CADM1, FOLR3, KYNU, and CNTNAP2 are core candidates for LSCC chemo-sensitivity. And that the low expression of CADM1 may result in chemo-sensitivity, which leads to high expression of gene FOLR3 and KYNU, and low expression of gene CNTNAP2. Besides, ROC analysis shows that these four genes exhibit effective diagnostic value for induction chemo-sensitivity.

Conclusions

CADM1 may be a potential molecular marker for LSCC induction chemotherapy, while CADM1, FOLR3, KYNU, and CNTNAP2 may provide essential guidance for LSCC diagnosis and follow-up treatment strategies.

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Acknowledgements

This work was supported by Beijing Municipal Administration of Hospitals Clinical Medicine Development of special funding support (XMLX20131), Beijing Municipal Administration of Hospitals Incubating Program (PX2018009), The Basic-Clinical Cooperation Fund, Capital Medical University (17JL76), The Golden Bridge Project, Beijing (JQ17031).

Author information

Authors and Affiliations

  1. Beijing Tongren Hospital, Capital Medical University, Beijing, China

    Lianhe Li, Ru Wang, Shizhi He, Xixi Shen, Meng Lian & Jugao Fang

  2. Central Hospital of Chaoyang, Liaoning, China

    Lianhe Li

  3. The Hospital of Shunyi District Beijing, Beijing, China

    Fanyong Kong

  4. School of Pharmaceutical Sciences, Minzu University of China, Beijing, China

    Shuchun Li & Huanhu Zhao

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  1. Lianhe Li
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  2. Ru Wang
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Correspondence to Meng Lian or Jugao Fang.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures involving human participants in this study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all patients included in the study.

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Table S1 The expression level of 13 differently expressed genes (XLSX 12 KB)

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Li, L., Wang, R., He, S. et al. The identification of induction chemo-sensitivity genes of laryngeal squamous cell carcinoma and their clinical utilization. Eur Arch Otorhinolaryngol 275, 2773–2781 (2018). https://doi.org/10.1007/s00405-018-5134-x

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  • DOI: https://doi.org/10.1007/s00405-018-5134-x

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