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Olfactory bulbus volume and olfactory sulcus depth in migraine patients: an MRI evaluation

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Objectives

To compare the measurements of olfactory bulb volume and olfactory sulcus depth in patients with migraine and a control group.

Methods

The study included the cranial MRI (1.5 T) images of 200 adults diagnosed with migraine and a control group of 100 subjects without migraine. The control group mainly consisted of the patients with non-migraneous headache. The measurements were obtained from coronal T2-weighted images for standard olfactory bulb (OB) volume and olfactory sulcus (OS) depth.

Results

The OB volume and OS depth values were lower in the migraine group than in the control group. In the migraine group, left OB volume of the males was significantly lower than those of the females. In both the migraine and control groups separately, the left-side OB volume values and the right side OS depth values were significantly greater than those of the contralateral side. There were positive correlations between right and left OB volume, and right and left OS depth values. No change was seen in OB volume and OS depth values according to gender. In older patients, a decrease was determined in the right and left OB volume, and the left-side OS depth values. There was a negative correlation between osmophobia and OB volume values. In migraine patients with osmophobia, the OB volume values were significantly decreased.

Conclusion

OB volume values were lower in migraine patients. When osmophobia was present, the OB volume was lower than that of the non-osmophobia migraine patients. Olfactory function monitoring with olfactory tests and olfactory volume monitoring on MRI can be recommended for all migraine patients to diagnose olfactory dysfunction earlier, especially those with osmophobia. Because their OB volume values were detected as lower than those of the migraine patients without osmophobia, it may be thought that blood flow changes and osmophobia may affect the olfactory bulb volume shrinkage in migraine patients.

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References

  1. Ertas M, Baykan B, Orhan EK, Zarifoglu M, Karli N, Saip S et al (2012) One-year prevalence and the impact of migraine and tension-type headache in Turkey: a nationwide home-based study in adults. J Headache Pain 13:147–157

    Article  PubMed  PubMed Central  Google Scholar 

  2. Jurgens TP, Schulte LH, May A (2014) Migraine trait symptoms in migraine with and without aura. Neurology 82:1416–1424

    Article  PubMed  Google Scholar 

  3. Charles A, Brennan KC (2010) The neurobiology of migraine. Handb Clin Neurol 97:99–108

    Article  PubMed  PubMed Central  Google Scholar 

  4. Yang W, Chu B, Yang J, Yu Y, Wu J, Yu S (2014) Elevated audiovisual temporal interaction in patients with migraine without aura. J Headache Pain 15:44

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Harriott AM, Schwedt TJ (2014) Migraine is associated with altered processing of sensory stimuli. Curr Pain Headache Rep 18:458

    Article  PubMed  Google Scholar 

  6. Leonardi M, Raggi A (2013) Burden of migraine: international perspectives. Neurol Sci 34(Suppl. 1):S117–S118

    Google Scholar 

  7. Fornazieri MA, Neto AR, de Rezende Pinna F, Gobbi Porto FH, de Lima Navarro P, Voegels RL et al (2016) Olfactory symptoms reported by migraineurs with and without auras. Headache 56(10):1608–1616

    Article  PubMed  Google Scholar 

  8. Baldacci F, Lucchesi C, Ulivi M, Cafalli M, Vedovello M, Vergallo A et al (2015) Clinical features associated with ictal osmophobia in migraine. Neurol Sci 36(1):43–6. https://doi.org/10.1007/s10072-014-1903-5 Epub 2014 Jul 29.

    Article  PubMed  Google Scholar 

  9. Saisu A, Tatsumoto M, Hoshiyama E, Aiba S, Hirata K (2011) Evaluation of olfaction in patients with migraine using an odour stick identification test. Cephalalgia 31(9):1023–1028

    Article  PubMed  Google Scholar 

  10. Zanchin G, Dainese F, Trucco M, Mainardi F, Mampreso E, Maggioni F (2007) Osmophobia in migraine and tension-type headache and its clinical features in patients with migraine. Cephalalgia 27:1061–1068

    Article  PubMed  CAS  Google Scholar 

  11. Sjostrand C, Savic I, Laudon-Meyer E, Hillert L, Lodin K, Waldenlind E (2010) Migraine and olfactory stimuli. Curr Pain Headache Rep 14:244–51

    Article  PubMed  Google Scholar 

  12. Lima AM, Sapienza GB, Giraud VO, Fragoso YD (2011) Odors as triggering and worsening factors for migraine in men. Arq Neuropsiquiatr 69:324–327

    Article  PubMed  Google Scholar 

  13. Kelman L (2004) The place of osmophobia and taste abnormalities in migraine classification: a tertiary care study of 1237 patients. Cephalalgia 24:940–946

    Article  PubMed  CAS  Google Scholar 

  14. .Rombaux P, Duprez T, Hummel T (2009) Olfactory bulb volume in the clinical assessment of olfactory dysfunction. Rhinology 47(1):3–9

    PubMed  CAS  Google Scholar 

  15. Headache Classification Committee of the International Headache Society (IHS) (2013) The international classification of headache disorders, 3rd edn (beta version) Cephalalgia 33(9):629–808

    Article  Google Scholar 

  16. Thierry P, Duprez A, Rombaux P (2010) Imaging the olfactory tract. Eur J Radiol 74:288–298

    Article  Google Scholar 

  17. Buschhüter D, Smitka M, Puschmann S, Gerber JC, Witt M, Abolmaali ND et al (2008) Correlation between olfactory bulb volume and olfactory function. Neuroimage 42:498–502

    Article  PubMed  Google Scholar 

  18. Rombaux P, Wetz H, Mouraux A, Nicolas G, Bertrand B, Duprez T et al (2006) Olfactory function assessed with orthonasal and retronasal testing, olfactory bulb volume and chemosensory event related potentials. Arch Otolaryngol Head Neck Surg 132:1346–1351

    Article  PubMed  Google Scholar 

  19. Kobal G, Klimek L, Wolfensberger M, Gudziol H, Temmel A, Owen CM et al. (2000) Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination and olfactory thresholds. Eur Arch Otorhinolaryngol 257: 205–11

    Article  Google Scholar 

  20. Heilmann S, Strehle G, Rosenheim K, Damm M, Hummel T (2002) Clinical assessment of retronasal olfactory function. Arch Otolaryngol Head Neck Surg 128:414–418

    Article  PubMed  Google Scholar 

  21. Frasnelli J, Landis BN, Heilmann S, Hauswald B, Hüttenbrink KB, Lacroix JS et al (2004) Clinical presentation of qualitative olfactory dysfunction. Eur Arch Otorhinolaryngol 261:411–415

    Article  PubMed  CAS  Google Scholar 

  22. Youssem DM, Geckle RJ, Doty RL (1995) Evaluation of olfactory deficits in neurodegenerative disorders. In: The Radiological Society of North America Scientific Program. Chicago, IL, USA, Abstract 271

  23. Mueller A, Abolmaali ND, Hakini AR, Gloeckler T, Herting B, Reichmann H et al (2005) Olfactory bulb volume in patients with idiopathic Parkinson’s disease—a pilot study. J Neural Transm 112:1363–1370

    Article  PubMed  CAS  Google Scholar 

  24. Hudspeth AJ (2000) Hearing. In: Kandel ER, Schwartz JH, Jessell TM (eds) Principles of neural science, 4th edn. The McGrawHill Companies, NewYork, pp 481–498

    Google Scholar 

  25. Rombaux P, Mouraux A, Bertrand B, Nicolas G, Duprez T, Hummel T (2006) Olfactory function and olfactory bulb volume in patients with postinfectious olfactory loss. Laryngoscope 116:436–439

    Article  PubMed  Google Scholar 

  26. Kayabaşoglu G, Altundag A, Kotan D, Dizdar D, Kaymaz R (2017) Osmophobia and olfactory functions in patients with migraine. Eur Arch Otorhinolaryngol 274(2):817–21

    Article  PubMed  Google Scholar 

  27. Demarquay G, Royet JP, Mick G, Ryvlin P (2008) Olfactory hypersensitivity in migraineurs: A H(2)(15)O-PET study. Cephalalgia 28:1069–1080

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Faculty of Medicine, Radiology Department, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey

    Adil Doğan

  2. Faculty of Medicine, ENT Department, Kırıkkale University, Kırıkkale, Turkey

    Nuray Bayar Muluk

  3. Faculty of Medicine, Radiology Department, Kırıkkale University, Kırıkkale, Turkey

    Mehmet Hamdi Şahan, Neşe Asal & Mikail Inal

  4. Faculty of Medicine, Neurology Department, Kırıkkale University, Kırıkkale, Turkey

    Ufuk Ergün

  5. Birlik Mahallesi, Zirvekent 2. Etap Sitesi, C-3 blok, No: 6-3/43, 06610, Çankaya/Ankara, Turkey

    Nuray Bayar Muluk

Authors
  1. Adil Doğan
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  2. Nuray Bayar Muluk
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  3. Mehmet Hamdi Şahan
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  4. Neşe Asal
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  5. Mikail Inal
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  6. Ufuk Ergün
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Contributions

Adil Doğan: planning, designing, data collection, literature survey. Nuray Bayar Muluk: planning, designing, literature survey, statistical analysis, writing. Mehmet Hamdi Şahan: planning, designing, data collection, literature survey. Neşe Asal: planning, designing, data collection, literature survey. Mikail Inal: planning, designing, data collection, literature survey. Ufuk Ergün: planning, designing, literature survey.

Corresponding author

Correspondence to Nuray Bayar Muluk.

Ethics declarations

Conflict of interest

The author Adil DOĞAN declares that he has no conflict of interest. The author Nuray BAYAR MULUK declares that she has no conflict of interest. The author Mehmet Hamdi ŞAHAN declares that he has no conflict of interest. The author Neşe ASAL declares that she has no conflict of interest. The author Mikail INAL declares that he has no conflict of interest. The author Ufuk ERGÜN declares that he has no conflict of interest.

Ethics committee approval

This study is retrospective. Ethics committee approval was obtained from Kırıkkale University Faculty of Medicine was also taken (Date 20.06.2017, Number: 16/03).

Informed consent

There is no need to take informed consent, because the data was evaluated retrospectively.

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Doğan, A., Bayar Muluk, N., Şahan, M.H. et al. Olfactory bulbus volume and olfactory sulcus depth in migraine patients: an MRI evaluation. Eur Arch Otorhinolaryngol 275, 2005–2011 (2018). https://doi.org/10.1007/s00405-018-5029-x

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  • DOI: https://doi.org/10.1007/s00405-018-5029-x

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