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Comparison of endoscopic and external resections for sinonasal instestinal-type adenocarcinoma

  • Rhinology
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Abstract

Endoscopic sinus surgery (ESS) is considered as a valid option in the management of nasal adenocarcinoma (ADC). Comparative studies with open approaches are still required. A monocentric retrospective study was carried out from May 2002 to December 2013, including 43 patients with intestinal-type adenocarcinoma of the ethmoid sinus. Non-resectable tumours or recurrences were excluded. Before 2008, open approach with lateral rhinotomy (LR) was performed as the gold standard of treatment. From 2008, ESS was systematically used as a first-line option as long as a complete resection was achievable. Adjuvant radiation therapy was delivered (RT) for all the patients. LR and ESS were performed in, respectively, 23 and 20 patients. The two groups were comparable in terms of age, occupational dust exposure, histopathological subtypes, and T stage based on the pathological assessment of the specimen (10 pT2, 26 pT3, 2 pT4a, and 5 pT4b). The tumour origin was mainly located in the olfactory cleft with the involvement of the cribriform plate in 60 % of patients. No major complication was observed in ESS group with a reduced hospital stay (5.6 vs 7.6 days). The disease-free survival was not different between LR and ESS groups over a mean follow-up period of 6.6 years. Even for local advanced stages with skull base involvement, we confirm the reliability and the advantages of ESS in terms of oncological outcomes and morbidity. We advocate complete excision of the olfactory cleft to ensure an appropriate control of the tumoral origin.

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Authors and Affiliations

  1. Otorhinolaryngology-Head and Neck Surgery Department, University Hospital, Lille, France

    Geoffrey Mortuaire, Claire Vandenhende-Szymanski, Dominique Chevalier & Anne-Sophie Thisse

  2. Université de Lille 2, Lille, France

    Geoffrey Mortuaire, Xavier Leroy & Dominique Chevalier

  3. Pathology Department, University Hospital, Lille, France

    Xavier Leroy

  4. Service d’ORL de chirurgie cervico-faciale, Hôpital Huriez CHRU Lille, Lille, 59000, France

    Geoffrey Mortuaire

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  1. Geoffrey Mortuaire
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Correspondence to Geoffrey Mortuaire.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Mortuaire, G., Leroy, X., Vandenhende-Szymanski, C. et al. Comparison of endoscopic and external resections for sinonasal instestinal-type adenocarcinoma. Eur Arch Otorhinolaryngol 273, 4343–4350 (2016). https://doi.org/10.1007/s00405-016-4181-4

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  • DOI: https://doi.org/10.1007/s00405-016-4181-4

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