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Genetic and clinical aspects of wood dust related intestinal-type sinonasal adenocarcinoma: a review

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Abstract

Intestinal-type sinonasal adenocarcinoma (ITAC) is a rare epithelial cancer of the nasal cavities and paranasal sinuses. Exposure to wood dust particles is a strong etiological factor making it a professional disease. These tumors are locally aggressive with frequent local recurrences in up to 50% of cases. Metastasis to regional lymph nodes and distant metastasis are less frequent (10%). Invasion of the duramater and local recurrence are frequent and the major cause of death. Standard therapeutic modalities include surgery followed by radiotherapy in advanced stages, sometimes with chemotherapy treatment. The molecular genetic mechanisms underlying the development and progression of this tumor is not understood. Histopathologically, ITAC resembles colorectal adenocarcinoma and have directed early genetic studies to search for similar genetic alterations. Recently, genome-wide studies have identified a recurrent pattern of chromosomal aberrations. This review aims to describe the clinico-pathological characteristics of this relatively unknown tumor and to summarize the knowledge on genetic and chromosomal analyses up to the present time.

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Acknowledgments

Authors thank Dr. Aurora Astudillo González, Department of Pathology, Hospital Universitario Central de Asturias, for the histopathological classification and the photomicrographs. This work was supported by grants CP30083 and PI05-1387 of Fondos de Investigación Sanitaria (FIS), Instituto Carlos III, Madrid, Spain.

Conflict of interest

The authors affirm that they have no conflicts of interest and have read and approved this manuscript, that has not been published previously and is not concurrently being considered by another journal.

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Authors and Affiliations

  1. Department of Otolaryngology, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Edificio H Covadonga 1ª Planta Centro, Lab 2, Hospital Universitario Central de Asturias, Celestino Villamil s/n, 33006, Oviedo, Spain

    José Luis Llorente, Jhudit Pérez-Escuredo, César Alvarez-Marcos, Carlos Suárez & Mario Hermsen

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  1. José Luis Llorente
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  2. Jhudit Pérez-Escuredo
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  3. César Alvarez-Marcos
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  4. Carlos Suárez
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  5. Mario Hermsen
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Correspondence to Mario Hermsen.

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Llorente, J.L., Pérez-Escuredo, J., Alvarez-Marcos, C. et al. Genetic and clinical aspects of wood dust related intestinal-type sinonasal adenocarcinoma: a review. Eur Arch Otorhinolaryngol 266, 1–7 (2009). https://doi.org/10.1007/s00405-008-0749-y

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  • DOI: https://doi.org/10.1007/s00405-008-0749-y

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