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Endoglin (CD105) expression in sinonasal polyposis

  • Rhinology
  • Published:
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Abstract

Despite appropriate surgical therapy, 5–10 % of patients with chronic rhinosinusitis (CRS) and nasal polyps (NP) experience disease recurrences. It has been suggested that angiogenesis may relate to the pathogenesis and prognosis of CRS with NP. Endoglin (CD105) is a component of the receptor complex of transforming growth factor-beta, a pleiotropic cytokine that modulates angiogenesis. A series of patients treated surgically for CRS with NP was analyzed to assess the relationship between CD105 expression, main clinicopathological features, and recurrence rate. The immunohistochemical expression of CD105 was assessed in 70 patients consecutively operated for CRS with NP. In the univariate setting, the presence of CD105 (1/0) showed a trend towards a significant association with increasing NP dimensions (p = 0.054). Intensity of CD105 reaction was also significantly associated with NP size (0.04) and with an eosinophilic histology (p = 0.048). In our multivariate setting, only asthma (p = 0.016), hypereosinophilia (p = 0.022), and preoperative polyposis score (p = 0.046) retained their independent prognostic significance in relation to NP recurrence. Further efforts are needed to elucidate the biological, angiogenic and proliferative mechanisms behind recurrent NP. Our preliminary results support the clinical utility of extra postoperative care, in terms of closer follow-ups and medication with oral anti-histamines, topical and/or oral steroids, and antileukotrienes in patients with asthma, advanced nasal polyposis at presentation, and serum hypereosinophilia.

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Acknowledgments

The authors thank Frances Coburn for correcting the English version of this paper. This study was partly supported by Grants No. 60A07-4322/13 (G. Ottaviano) and No. 60A07-1341/12 (G. Marioni) from the University of Padova, Italy.

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Authors and Affiliations

  1. Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy

    Giancarlo Ottaviano, Ioannis Mylonakis, Marco Lionello, Niccolò Favaretto, Rosario Marchese-Ragona, Alberto Staffieri, Alessandro Martini & Gino Marioni

  2. Department of Medicine DIMED, Padova University, Padua, Italy

    Rocco Cappellesso, Luciano Giacomelli, Cristiano Spoladore & Filippo Marino

Authors
  1. Giancarlo Ottaviano
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  2. Rocco Cappellesso
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  3. Ioannis Mylonakis
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  4. Marco Lionello
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  5. Niccolò Favaretto
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  6. Luciano Giacomelli
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  7. Cristiano Spoladore
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  8. Rosario Marchese-Ragona
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  9. Filippo Marino
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  10. Alberto Staffieri
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  11. Alessandro Martini
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  12. Gino Marioni
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Correspondence to Giancarlo Ottaviano.

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Ottaviano, G., Cappellesso, R., Mylonakis, I. et al. Endoglin (CD105) expression in sinonasal polyposis. Eur Arch Otorhinolaryngol 272, 3367–3373 (2015). https://doi.org/10.1007/s00405-014-3456-x

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  • DOI: https://doi.org/10.1007/s00405-014-3456-x

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