Abstract
Clinical studies have shown that Helicobacter pylori can be found not only in the mucosa of the stomach, but in the pharyngeal and laryngeal regions as well. The aim of this prospective case-control study was to identify H. pylori infection in the biopsy material from the larynx of the patients suffering from benign laryngeal diseases (vocal fold polyps, laryngitis) and laryngeal cancer and to investigate the possible relationships between the laryngeal H. pylori and patients’ socio-demographic data and laryngopharyngeal reflux. The results of the biopsy material from 67 adult patients treated for benign laryngeal diseases and laryngeal cancer and 11 individuals of the control group revealed that H. pylori infection could be identified in more than one-third of the patients. In the majority of cases H. pylori was found in the patients with chronic laryngitis (45.5 %) and laryngeal cancer (46.2 %). The findings of these sub-groups significantly differed from those of the control group (9.1 %) (p < 0.05). No significant relationships between H. pylori infection found in the laryngeal region and patients’ demographic data, their unhealthy habits and reflux-related symptoms or signs were obtained. It could be concluded that H. pylori can colonize in the larynx of patients with benign laryngeal diseases and laryngeal cancer. To clarify the role of H. pylori as a risk factor for laryngeal diseases further research is needed.
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References
Kupčinskas L (2000) The relationship between gastroduodenal diseases and Helicobacter pylori infection. Dissertation, Kaunas Medical University
Labanauskas L, Kucinskiene R, Urbonas V et al (2008) Relevance of examination and treatment of the most common gastrointestinal disorders in children in Lithuania during the last decade. Medicina (Kaunas) 44:72–80
Malfertheiner P, Megraud F, O’Morain CA et al (2012) Management of Helicobacter pylori infection-the Maastricht IV/florence consensus report. Gut 61(5):646–664
Kusano K, Inokuchi A, Fujimoto K et al (2010) Coccoid Helicobacter pylori exists in the palatine tonsils of patients with IgA nephropathy. J Gastroenterol 45(4):406–412
Gong H, Shi Y, Zhou L et al (2012) Helicobacter pylori infection of the larynx may be an emerging risk factor for laryngeal squamous cell carcinoma. Clin Transl Oncol 14(12):905–910
Rezaii J, Tvakoli H, Esfandriaki K et al (2008) Association between Helicobacter pylori infection and laryngohypopharyngeal carcinoma: a case study and review of the literature. Head Neck 30(12):1624–1627
Zhuo XL, Wang Y, Zhuo WL et al (2008) Possible association of Helicobacter pylori infection with laryngeal cancer risk: an evidence-based meta-analysis. Arch Med Res 39(6):625–628
Belafsky PC, Postma GN, Amin MR, Koufman JA (2002) Symptoms and findings of laryngopharyngeal reflux. Ear Nose Thoat J 81:10–13
Belafsky PC, Postma GN, Koufman JA (2001) The validity and reliability of the Reflux Finding Score (RFS). Laryngoscope 111:1313–1317
Jančiauskas D (2010) Histomorphological changes of gastric mucosa in functional dyspepsia patients and their dynamics after treatment with the natural antioxidant astaxanthin. Dissertation, Kaunas Medical University
Tseng CA, Wang WM, Wu DC (2000) Comparison of the clinical feasibility of three rapid urease tests in the diagnosis of Helicobacter pylori infection. Dig Dis Sci 50(3):449–452
Pajić-Penavić I, Danić D, Maslovara S et al (2012) Absence of Helicobacter pylori in healthy laryngeal mucosa. J Laryngol Otol 126(2):196–199
Burduk PK (2006) The role of Helicobacter pylori infection in carcinoma of the larynx. Otolaryngol Pol 60(4):521–523
Aygenc E, Selcuk A, Celikkanat S et al (2001) The role of Helicobacter pylori infection in the cause of squamous cell carcinoma of the larynx. Otolaryngol Head Neck Surg 125(5):520–521
Burduk PK, Kaczmarek A, Budzynska A et al (2011) Detection of Helicobacter pylori and cagA gene in nasal polyps and benign laryngeal diseases. Arch Med Res 42(8):686–689
Cekin E, Ozyurt M, Erkul E et al (2012) The association between Helicobacter pylori and laryngopharyngeal reflux in laryngeal pathologies. Ear Nose Throat J 91(3):E6–E9
Ozyurt M, Gungor A, Ergunay K et al (2009) Real-time PCR detection of Helicobacter pylori and virulence-associated cagA in nasal polyps and laryngeal disorders. Otolaryngol Head Neck Surg 141(1):131–135
Tiba M, Fawaz S, Osman H (2010) Helicobacter pylori and its role in vocal folds’ minimal lesions. Clin Respir J 4(4):237–240
Izadi F, Ahmadi A, Ghourchian S et al (2012) Detection of Helicobacter pylori in benign laryngeal lesions by polymerase chain reaction: a cross sectional study. Infect Agent Cancer 7:10. doi:10.1186/1750-9378-7-10
Fang TJ, Lee LA, Li HY et al (2008) Helicobacter pylori colonization in the larynges of patients with hoarseness. Laryngoscope 118:389–393
Titiz A, Ozcakir O, Ceyhan S et al (2008) The presence of Helicobacter pylori in the larynx pathologies. Auris Nasus Larynx 35(4):534–538
Ercan I, Cakir BO, Uzel TS et al (2006) The role of gastric Helicobacter pylori infection in laryngopharyngeal reflux disease. Otolaryngol Head Neck Surg 135(1):52–55
Oridate N, Takeda H, Yamamoto J et al (2006) Helicobacter pylori seropositivity predicts outcomes of acid suppression therapy for laryngopharyngeal reflux symptoms. Laryngoscope 116(4):547–553
Tauber S, Gross M, Issing WJ et al (2002) Association of laryngopharyngeal symptoms with gastroesophageal reflux disease. Laryngoscope 112(5):879–886
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Siupsinskiene, N., Jurgutaviciute, V., Katutiene, I. et al. Helicobacter pylori infection in laryngeal diseases. Eur Arch Otorhinolaryngol 270, 2283–2288 (2013). https://doi.org/10.1007/s00405-013-2475-3
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DOI: https://doi.org/10.1007/s00405-013-2475-3