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Gender-based personalized pharmacotherapy: a systematic review

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Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

In general, male and female are prescribed the same amount of dosage even if most of the cases female required less dosage than male. Physicians are often facing problem on appropriate drug dosing, efficient treatment, and drug safety for a female in general. To identify and synthesize evidence about the effectiveness of gender-based therapy; provide the information to patients, providers, and health system intervention to ensure safety treatment; and minimize adverse effects.

Methods

We performed a systematic review to evaluate the effect of gender difference on pharmacotherapy. Published articles from January 1990 to December 2015 were identified using specific term in MEDLINE (PubMed), EMBASE, and the Cochrane library according to search strategies that strengthen the reporting of observational and clinical studies.

Results

Twenty-six studies fulfilled the inclusion criteria for this systematic review, yielding a total of 6309 subjects. We observed that female generally has a lower the gastric emptying time, gastric PH, lean body mass, and higher plasma volume, BMI, body fat, as well as reduce hepatic clearance, difference in activity of Cytochrome P450 enzyme, and metabolize drugs at different rate compared with male. Other significant factors such as conjugation, protein binding, absorption, and the renal elimination could not be ignored. However, these differences can lead to adverse effects in female especially for the pregnant, post-menopausal, and elderly women.

Conclusion

This systematic review provides an evidence for the effectiveness of dosage difference to ensure safety and efficient treatment. Future studies on the current topic are, therefore, recommended to reduce the adverse effect of therapy.

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Abbreviations

BMR:

Basal metabolic rates

CO:

Cardiac output

CYP3A:

Cytochrome P450-3A

GFR:

Glomerular filtration rate

GST:

Glutathione-S-transferase isoenzymes

PGP:

p-Glycoprotein

UGT:

Uridine diphosphate glucoronosyl transferase

ADR:

Adverse drug reaction

CYP1A2:

Cytochrome P450-1A2

GD:

Glomerular density

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Acknowledgements

This research is sponsored in part by the Ministry of Science and Technology (MOST) under grant MOST 103-2221-E-038-014-, MOST 103-2221-E-038-016-, MOST 104-2221-E-038-013, and MOST 104-3011-E-038 -001; Health and welfare surcharge of tobacco products grant MOHW104-TDU-B-212-124-001, Ministry of Education, Taiwan, under grant TMUTOP103006-6.

Author contributions

Md. Mohaimenul Islam: writing manuscript and data collection. Jakir Hossain Bhuiyan Masud; Usman Iqbal; Suleman Atique, Navneet Kumar Dubey; Phung-Anh Nguyen; Tahmina Nasrin Poly: data collection and arranging manuscript. Bruno Andreas Walther: edit the manuscript. Yu-Chuan (Jack) Li; Shabbir Syed-Abdul: protocol development and manuscript checking.

Author information

Authors and Affiliations

  1. Graduate Institution of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan

    Md. Mohaimenul Islam, Phung-Anh Nguyen, Yu-Chuan (Jack) Li, Jakir Hossain Bhuiyan Masud, Suleman Atique & Shabbir Syed-Abdul

  2. International Center for Health Information Technology (ICHIT), Taipei Medical University, Taipei, Taiwan

    Md. Mohaimenul Islam, Usman Iqbal, Phung-Anh Nguyen, Yu-Chuan (Jack) Li, Jakir Hossain Bhuiyan Masud, Suleman Atique & Shabbir Syed-Abdul

  3. Master Program in Global Health and Development, College of Public Health, Taipei Medical University, Taipei, Taiwan

    Usman Iqbal & Bruno Andreas Walther

  4. Chair, Department of Dermatology, Wan Fang Hospital, Taipei, Taiwan

    Yu-Chuan (Jack) Li

  5. Graduate Institute of Biomedical Materials & Tissue Engineering, Taipei Medical University, Taipei, Taiwan

    Navneet Kumar Dubey

  6. Department of Microbiology and Immunology, Tzu Chi University, Hualien, Taiwan

    Tahmina Nasrin Poly

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  1. Md. Mohaimenul Islam
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  5. Yu-Chuan (Jack) Li
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Corresponding author

Correspondence to Shabbir Syed-Abdul.

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Since this is a review paper, ethical considerations are not applicable.

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Islam, M.M., Iqbal, U., Walther, B.A. et al. Gender-based personalized pharmacotherapy: a systematic review. Arch Gynecol Obstet 295, 1305–1317 (2017). https://doi.org/10.1007/s00404-017-4363-3

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  • DOI: https://doi.org/10.1007/s00404-017-4363-3

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