Abstract
Several clinical observations and animal experiments have led to speculation concerning the possible effects of pregnancy and pregnancy-associated sex steroids on gastrointestinal function. It was reported that estrogen increases intestinal contractile activity, while progesterone or the combination of estrogen and progesterone decreases it. In order to measure gastric emptying, a methylcellulose test meal was given orally into the stomach of conscious rats. In progesteronetreated rats, at the dose of 0.2 mg/kg, gastric emptying was not significantly different from that of the control, but it was found to be significantly delayed at the dose of 10 mg/kg (P<0.05). Estrogen treatment at doses of 20 μg/kg and 600 μg/kg significantly delayed gastric emptying, when compared with controls (P<0.001). Combined therapy of estrogen and progesterone induced a significant delay in gastric emptying rate compared with the control group (P<0.001). In the animals with pseudopregnancy treatment (100 μg/kg estrogen+ 15 mg/kg progesterone; 7–12 days) the gastric empying rate was significantly different from that of the control (P<0.05). We conclude that both estrogen and progesterone exert inhibitory effects on gastric emptying, and this may account for the disturbances in gastrointestinal function that pregnant women frequently experience.
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References
Hytten FE, Leitch I (1971) Alimentary function in the physiology of human pregnancy, 2nd edn. Blackwell Scientific Publications, Oxford, pp 165–178
Winship DH (1975) Gastrointestinal diseases. In: Burrow GN, Ferris TF (eds) Medical complications during pregnancy. Saunders, Philadelphia, pp 275–350
Benson RC (1976) Medical and surgical complications during pregnancy. In: Benson RC (ed) Current obstetrics and gynecologic diagnosis. Lange Medical Publications, Los Altos, pp 722–745
Everson GT (1992) Gastrointestinal motility in pregnancy. Gastroenterol Clin North Am 21:751–775
Datta S, Hey VM, Pleuvry BJ (1974) Effects of pregnancy and associated hormones in mouse intestine, in vivo and in vitro. Pflügers Arch 346:87–95
Bruce LA, Beschudi FM (1980) Differential inhibition of regional gastrointestinal tissue to progesterone in the rat. Life Sci 27:427–434
Bruce LA, Beshudi FM (1981) Increased gasrointestinal motility in vitro following chronic estrogen treatment in male rats (41703). Proc Soc Exp Biol Med 166:355–359
Ryan JP, Bhojwani A (1986) Colonic transits in rats: effect of ovariectomy, sex steroid hormones, and pregnancy. Am J Physiol 251:G46-G50
Milenov K, Kazakov L (1973) Influence of ovarian hormones on electromyograms of uterus, stomach and intestines in dogs. Endocrinol Exp 7:163–170
Bruce LA, Behsudi FM (1979) Progesterone effects on three regional gastrointestinal tissues. Life Sci 25:729–734
Bruce LA, Behsudi FM, Danhof IE (1978) Smooth muscle mechnical responses in vitro to bethanechol after progesterone in male rat. Am J Physiol 235:E422-E428
Hutson WR, Roehrkasse RL, Wald A (1989) Influence of gender and menopause on gastric emptying and motility. Gastroenterology 96:11–17
Ryan JP, Bhojwani A, Wang WB (1987) Effect of pregnancy on gastric motility in vivo and in vitro in the guinea pig. Gastroenterology 93:29–34
Schulze K, Christensen J (1977) Lower sphincter of the opossum esophagus in pseudopregnancy. Gastroenterology 73:1082–1085
Scarpignato C, Capovilla T, Bertaccini G (1980) Action of caerulein on gastric emptying of conscious rat. Arch Int Pharmacodyn Ther 246:286–294
Tache Y, Madea-Hagiwara M, Turkelson CM (1987) Central nervous system action of cortropin-releasing factor to inhibit gastric emptying in rats. Am J Physiol 253:G241-G245
Wald A, Van Thiel DH, Hoechstetter L, Gavaler JS, Egler KM, Verm R, Scott L, Lester R (1981) Intestinal transit: the effect of the menstrual cycle. Gastroenterology 80: 1497–1500
Turnbull GK, Thompson DG, Day S, Martin J, Walker E, Lennard-Jones JE (1989) Relationships between symptoms, menstrual cycle and orocaecal transit in normal and constipated women. Gut 30:30–34
Wald A, Van Thiel DH, Hoechstetter L, Gavaler JS, Egler KM, Verm R, Scott L, Lester R (1982) Effect of pregnancy on gastrointestinal transit. Dig Dis Sci 27:1015–1018
Ryan JP, Pellecchia D (1982) Effect of progesterone pretreatment on guinea pig gall bladder motility in vitro. Gastroenterology 83:81–83
Davis M, Ryan JP (1986) Influence of progesterone on guinea pig gall bladder motility in vitro. Dig Dis Sci 31:513–518
Kumar D (1962) In vitro inhibitory effect of progesterone on extrauterine human smooth muscle. Am J Obstet Gynecol 84:1300–1304
Gill RC, Bowes KL, Kingma YJ (1985) Effect of progesterone on canine colonic smooth muscle. Gastroenterology 88:1941–1947
Milenov K (1976) Effect of estradiol, progesterone and oxytocin on smooth muscle activity In: Bulbring E, Shuba MF (eds) Physiology of smooth muscle. Raven Press, New York, pp 395–402
Csapo AI (1961) The in vivo and in vitro effects of estrogen and progesterone on the myometrium. In: Vilee CA, Engel LL (eds) Mechanism of action of steroid hormones. Academic Press, New York, pp 68–74
Fisher RS, Roberts GS, Grabowski CJ, Cohen S (1978) Inhibition of lower esophageal sphincter circular muscle by female sex hormones. Am J Physiol 234:E243-E247
Depue RH, Bernstein L, Ross RK, Judd HL, Henderson BE (1987) Hyperemesis gravidarum in relation to estradiol levels, pregnancy outcome, and other maternal factors; a seroepidemiologic study. Am J Obstet Gynecol 156:1137–1141
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Coşkun, J., Sevinç, A., Tevetoğlu, I. et al. Delayed gastric emptying in conscious male rats following chronic estrogen and progesterone treatment. Res. Exp. Med. 195, 49–54 (1995). https://doi.org/10.1007/BF02576773
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DOI: https://doi.org/10.1007/BF02576773