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Serum vitamin D status and in vitro fertilization outcomes: a systematic review and meta-analysis

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

To assess the correlation between serum 25-hydroxy vitamin D [25(OH)D] status and outcomes of in vitro fertilization (IVF) in infertile women through review systematically.

Methods

We used Embase, Pubmed, and Cochrane database to identify all studies that assessed the correlation between serum vitamin D levels and IVF outcomes in infertile women up until 30 June 2015, with the restricted language of English. We included studies that compared IVF outcomes between infertile women vitamin D <20 ng/ml and vitamin D ≥20 ng/ml. The results were summarized using Stata 12.0 software. For studies reported dichotomous outcomes (clinical pregnancy rate and live birth rate), we pooled the relative risks ratios (RRs) and 95 % confidence intervals (CIs) in a random effects model.

Results

Our search resulted in the retrieval and screening of 134 studies. Of those, five studies were included in our meta-analysis. The risk for lower clinical pregnancy rate was not significantly increased in the deficient group (RR 0.88, 95 % CI 0.69–1.11). Lower vitamin D status was associated with lower live birth rate (RR 0.76, 95 % CI 0.61–0.93).

Conclusion

There is no significant correlation between deficient serum vitamin D level and lower clinical pregnancy rate in infertile woman undergoing in vitro fertilization. On the other hand, deficient vitamin D level was related to lower live birth rate.

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Authors and Affiliations

  1. Department of Endocrinology, The People’s Hospital of Deyang City, Deyang, 618000, Sichuan, China

    Shi Shi Lv, Xiao Qian Wang & Yan Wang

  2. Department of Endocrinology, Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, Sichuan, China

    Ji Ying Wang & Yong Xu

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  1. Shi Shi Lv
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  4. Yan Wang
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Correspondence to Yong Xu.

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We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, and there is no professional or other personal interest of any nature or kind in any product, service, and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitled, “Serum vitamin D status and In Vitro Fertilization Outcomes: A Systematic Review and Meta-analysis.”

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Lv, S.S., Wang, J.Y., Wang, X.Q. et al. Serum vitamin D status and in vitro fertilization outcomes: a systematic review and meta-analysis. Arch Gynecol Obstet 293, 1339–1345 (2016). https://doi.org/10.1007/s00404-016-4058-1

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