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Perinatal survival and procedure-related complications after intrauterine transfusion for red cell alloimmunization

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objectives

To study the perinatal survival and procedure-related (PR)complications after intrauterine transfusions in red cell alloimmunization.

Methods

Prospective data of 102 women with Rh-alloimmunized pregnancy undergoing intrauterine intravascular transfusion for fetal anemia, from January 2011 to October 2014 were analyzed. Main outcome measures were perinatal survival and procedure-related (PR) complications.

Results

A total of 303 intrauterine transfusions were performed in 102 women. Of 102 fetuses, 22 were hydropic at first transfusion. The mean period of gestation and hematocrit at first transfusion was 26.9 ± 3.3 weeks (range 19.7–33.8 weeks) and 17 ± 7.82 % (range 5.7–30 %), respectively. Average number of transfusions was 2.97 (range 1–7) per patient. Overall survival was 93 % and mean period of gestation at delivery was 34.5 ± 1.94 (range 28.3–37.4) weeks. Mean hematocrit at delivery was 36.9 ± 8.77 % (range 10–66 %). Fetal death occurred in four cases (3PR), neonatal death occurred in three cases (2PR). Emergency cesarean delivery after transfusion was performed in four pregnancies. The total PR complication rate was 2.97 %, resulting in overall PR loss in 1.65 % per procedure.

Conclusion

Our results compare favorably with other studies published in the literature. Intravascular transfusion is a safe procedure improving perinatal survival in fetuses with anemia due to Rh-alloimmunization.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology and Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India

    Dipika Deka, Vatsla Dadhwal, Aparna K. Sharma, Unnati Shende, Sumita Agarwal, Ramesh Agarwal & Perumal Vanamail

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  1. Dipika Deka
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  2. Vatsla Dadhwal
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  3. Aparna K. Sharma
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  4. Unnati Shende
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  5. Sumita Agarwal
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  6. Ramesh Agarwal
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  7. Perumal Vanamail
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Corresponding author

Correspondence to Vatsla Dadhwal.

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Conflict of interest

There are no conflicts of interest.

Author contribution

Deka D: Protocol/project development (Patient management protocols). Vatsla D: Protocol/project development, Data management, Manuscript writing. Sharma KA: Protocol/project development, Data collection and management. Shende U: Data collection. Agarwal S: Data Collection. Agarwal R: Protocol/project development (neonatal management). Perumal V: Data analysis.

Additional information

This research has not been sponsored by any organisation. The authors have full control of all primary data and that they would agree to allow the Journal to review their data if requested.

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Deka, D., Dadhwal, V., Sharma, A.K. et al. Perinatal survival and procedure-related complications after intrauterine transfusion for red cell alloimmunization. Arch Gynecol Obstet 293, 967–973 (2016). https://doi.org/10.1007/s00404-015-3915-7

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  • DOI: https://doi.org/10.1007/s00404-015-3915-7

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