Abstract
Purpose
To date, case–control studies on the association between a single-nucleotide polymorphism (SNP) in the plasminogen activator inhibitor-1 (PAI-1) gene and polycystic ovary syndrome (PCOS) have provided controversial results.
Methods
The electronic databases PubMed, Embase, Web of Science, and CNKI (China National Knowledge Infrastructure) were searched for studies to include in the present meta-analysis.
Results
The fixed effects and random effects models showed that the 4G allele was associated with a risk of PCOS compared with the 5G allele in Chinese patients (OR = 2.05; 95 % CI = 1.56–2.69), but not in Caucasian patients (OR = 1.05; 95 % CI = 0.81–1.37). The contrast of homozygotes and the recessive and dominant models produced the same pattern of results as the allele contrast.
Conclusion
Our pooled data suggest evidence for a major role of PAI-1 gene 4G/5G polymorphism in the pathogenesis of PCOS among Chinese patients.
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We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and company that could be construed as influencing the position presented in, or the review of, the manuscript.
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Wang, LH., Wang, LM. & Zhou, N. 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with polycystic ovary syndrome in Chinese patients: a meta-analysis. Arch Gynecol Obstet 292, 683–686 (2015). https://doi.org/10.1007/s00404-015-3678-1
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DOI: https://doi.org/10.1007/s00404-015-3678-1