Abstract
Purpose
To analyze the changes in the endometrial thickness in infertile polycystic ovary syndrome (PCOS) patients throughout an entire menstrual cycle and compare the changes to those seen in infertile patients without PCOS.
Methods
This prospective, cross-sectional study was conducted in a total of 58 non-obese, infertile women with PCOS. The endometrial thickness was measured at three different times throughout the menstrual cycle by ultrasound. Age- and body mass index (BMI)-matched control group consisted of 62 non-obese infertile patients without PCOS. Demographic, hormonal and the ultrasonographic measurements of the two groups were compared.
Results
Day 3 levels of LH were significantly different between the groups (p = 0.013). Ovarian volume measurement was significant between the groups (p = 0001). All the endometrial thickness measurements in the early, mid-cycle and late luteal phases were also significantly different; p = 0.001 for all.
Conclusion
The study demonstrated an increased endometrial stripe measurements throughout a menstrual cycle in infertile patients with PCOS, when compared to infertile patients without PCOS.
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References
Franks S (1995) Polycystic ovary syndrome. N Engl J Med 333:853–861
Kabli N, Tulandi T (2008) Medical management of polycystic ovary syndrome. In: Infertility and assisted reproduction. Cambridge University Press New York, pp:286-293
Balen AH, Tan SL, MacDougall J, Jacobs HS (1993) Miscarriage rates following in vitro fertilization are increased in women with polycystic ovaries and reduced by pituitary desensitization with buserelin. Hum Reprod 8:959–964
Rudnicka E, Wierzba W, Radowicki S (2009) Evaluation of endometrial histologic morphology in patients with polycystic ovary syndrome. Ginekol Pol 80:103–106
Chittenden BG, Fullerton G, Maheshwari A, Bhattacharya S (2009) Polycystic ovary syndrome and the risk of gynaecological cancer: a systematic review. Reprod Biomed Online 19:398–405
Wang J, Davies M, Norman R (2001) Polycystic ovarian syndrome and the risk of spontaneous abortion following assisted reproductive technology treatment. Hum Reprod 16:2606–2609
Matteo M, Serviddio G, Massenzio F et al (2010) Reduced percentage of natural killer cells associated with impaired cytokine network in the secretory endometrium of infertile women with polycystic ovary syndrome. Fertil Steril 94(6):2222–2227
Kohan K, Carvajal R, Gabler F, Vantman D, Romero C, Vega M (2010) Role of the transcriptional factors FOXO1 and PPARG on gene expression of SLC2A4 in endometrial tissue from women with polycystic ovary syndrome. Reproduction 140:123–131
Okan M, Laird S, Tuckerman E, Li T (1998) Serum androgen levels in women who have recurrent miscarriages and their correlation with markers of endometrial function. Fertil Steril 69:682–690
Ozkan S, Vural B, Calıskan E, Bodur H, Türköz H, Vural F (2007) Color Doppler sonographic analysis of uterine and ovarian artery blood flow in women with polycystic ovary syndrome. J Clin Ultrasound 35:305–313
Cheung AP (2001) Ultrasound and Menstrual History in Predicting Endometrial Hyperplasia in Polycystic Ovary Syndrome. Obstet Gynecol 98(2):325–331
McCormick BA, Wilburn RD, Thomas MA, Williams DB, Maxwell R, Aubuchon M (2011) Endometrial thickness predicts endometrial hyperplasia in patients with polycystic ovary syndrome. Fertil Steril 95(8):2625–2627
Peri N, Levine D (2007) Sonographic Evaluation of the Endometrium in Patients With a History or an Appearance of Polycystic Ovarian Syndrome. J Ultrasound Med 26:55–58
The Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) (2004) Hum Reprod 19: 41–47
OrsiniLF VenturoliS, Lorusso R (1985) Ultrasonic findings in polycystic ovarian disease. Fertil Steril 43:709–714
Knochenhauer ES, Key TJ, Kahsar-Miller M, Waggoner W, Boots LR, Azziz R (1998) Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study. J Clin Endocrinol Metab 83(9):3078–3082
Casper RF (2011) It’s time to pay attention to the endometrium. Fertil Steril 96(3):519–521
Lam P, Johnson I, Raina-Fenning N (2009) Endometrial blood flow is impaired in women with polycystic ovarian syndrome who are clinically hyperandrogenic. Ultrasound Obstet Gynecol 34:326–334
Dickey RP, Olar TT, Curole DN, Taylor SN, Rye PH (1992) Endometrial pattern and thickness associated with pregnancy outcome after assisted reproduction technologies. Hum Reprod 7:418–421
Bergh C, Hillensj€o T, Nilsson L (1992) Sonographic evaluation IVF cycles. Away to predict pregnancy? Acta Obstet Gynecol Scand 71:624–628
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Eryilmaz, O.G., Sarikaya, E., Gulerman, C. et al. Endometrial thickness measurement throughout a menstrual cycle in non-obese infertile patients with polycystic ovary syndrome. Arch Gynecol Obstet 286, 1597–1600 (2012). https://doi.org/10.1007/s00404-012-2488-y
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DOI: https://doi.org/10.1007/s00404-012-2488-y