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Histomorphometric Analysis and Markers of Endometrial Receptivity Embryonic Implantation in Women With Polycystic Ovary Syndrome During the Treatment With Progesterone

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Abstract

Literature data indicate that the infertility in women with polycystic ovary syndrome (PCOS) is not only attributed to anovulation but also to endometrial dysfunction. Endometrial biopsies were performed in the proliferative and secretory phases of women with normal cycle and in women with PCOS before and after oral treatment with micronized progesterone. After the treatment, the endometrium of the women with PCOS exhibited a lower number of glands and thicker luminal epithelium compared to the normal women in the secretory phase. In addition, the PCOS group exhibited reduced integrin and MECA-79 immunoexpression during the secretory phase. The expression of E-cadherin was higher in the PCOS and the expression of intercellular adhesion molecule 1 was lower in PCOS, during the secretory and proliferative phases, respectively. Also, there is a negative correlation with MECA-79 and integrin expression and body mass index. Conventional doses of progesterone may not be enough to correct the changes of endometrial histomorphology and the receptive markers of PCOS-bearing women. The obesity may be a factor that interferes with this response.

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Authors and Affiliations

  1. Departamento Materno Infantil, Centro de Ciências da Saúde, Universidade Federal do Piauí, UFPI, Teresina, Brazil

    Ione Maria Ribeiro Soares Lopes MD, PhD

  2. Departamento de Ginecologia, Departamento de Ginecologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, EPM/UNIFESP, Brazil

    Carla Cristina Maganhin PhD, Manuel Jesus Simões PhD, Margareth Chiharu Iwata MD & José Maria Soares Jr MD, PhD

  3. Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, USP, São Paulo, Brazil

    Ricardo Martins Oliveira-Filho PhD

  4. Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina da Universidade de São Paulo, FMUSP, São Paulo, Brazil

    Ricardo Santos Simões MD, Edmund Chada Baracat MD, PhD & José Maria Soares Jr MD, PhD

  5. Rua três de maio, 154 - Apto 61, São Paulo (SP), CEP 04235 010, Brazil

    Ricardo Santos Simões MD

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  1. Ione Maria Ribeiro Soares Lopes MD, PhD
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  2. Carla Cristina Maganhin PhD
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  3. Ricardo Martins Oliveira-Filho PhD
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  4. Ricardo Santos Simões MD
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  5. Manuel Jesus Simões PhD
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  7. Edmund Chada Baracat MD, PhD
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  8. José Maria Soares Jr MD, PhD
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Correspondence to Ricardo Santos Simões MD.

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Lopes, I.M.R.S., Maganhin, C.C., Oliveira-Filho, R.M. et al. Histomorphometric Analysis and Markers of Endometrial Receptivity Embryonic Implantation in Women With Polycystic Ovary Syndrome During the Treatment With Progesterone. Reprod. Sci. 21, 930–938 (2014). https://doi.org/10.1177/1933719113519169

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  • DOI: https://doi.org/10.1177/1933719113519169

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