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Type I collagen and matrix metalloproteinase 1, 3 and 9 gene polymorphisms in the predisposition to pelvic organ prolapse

  • General Gynecology
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Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Aim

To evaluate whether the presence of specific polymorphism in the gene promoter of collagen and some matrix metalloproteinases was associated with the risk of developing pelvic organ prolapse.

Methods

A case–control study was carried on 233 women: 137 were cases with ≥stage II pelvic organ prolapse and 96 were matched controls without pelvic pathologies. Allele and genotype frequencies related to polymorphisms at the Sp1 site of type I collagen and some functional polymorphisms in the promoters of metalloproteinases-1, -3 and -9 have been compared between groups. It has been shown that these single-insertions/deletions polymorphisms located in the promoter region of the genes have a functional significance in the regulation of their transcriptional level and local expression. Genotypes were determined by polymerase chain reaction (PCR) amplification and sequence analysis. SPSS 14.0 software was used for data analysis. Probability values of <0.05 were considered statistically significant.

Results

No difference between groups was found in the genotype distribution polymorphisms for COL1A1, metalloproteinases-9 and -3, while the distribution of the polymorphism of metalloproteinases-1 was significantly increased in the cases when compared with controls (p = 0.04).

Conclusions

Our findings suggest that the polymorphism of metalloproteinases-1 might have a role in mediating susceptibility to pelvic organ prolapse.

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Conflict of interest

The authors have no financial, personal, political, intellectual or religious interests to disclose.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, IRCCS Fondazione Policlinico Mangiagalli e Regina Elena, Milan, Italy

    Maria Maddalena Ferrari & Chiara Dell’Utri

  2. Department of Obstetrics and Gynecology, Ospedale G. Fornaroli, Magenta, Italy

    Gabriela Rossi & Michele Meschia

  3. Department of Medicina Chirurgia e Odontoiatria, Milan, Italy

    Maria Luisa Biondi

  4. Obstetrics and Gynecology Unit, Scientific Institute San Raffaele, Milan, Italy

    Paola Viganò

Authors
  1. Maria Maddalena Ferrari
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  2. Gabriela Rossi
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  3. Maria Luisa Biondi
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  4. Paola Viganò
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  5. Chiara Dell’Utri
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  6. Michele Meschia
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Correspondence to Michele Meschia.

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Ferrari, M.M., Rossi, G., Biondi, M.L. et al. Type I collagen and matrix metalloproteinase 1, 3 and 9 gene polymorphisms in the predisposition to pelvic organ prolapse. Arch Gynecol Obstet 285, 1581–1586 (2012). https://doi.org/10.1007/s00404-011-2199-9

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  • DOI: https://doi.org/10.1007/s00404-011-2199-9

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