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Primary metastasized extraskeletal Ewing sarcoma of the vulva: report of a case and review of the literature

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

Ewing’s sarcoma (ES) and primitive neuroectodermal tumor (PNET) are closely related malignant neoplasms, usually affecting the skeletal system. Extraosseous ES/PNETs are uncommon, with occasional reports of tumors affecting the genitourinary tract. Only few cases of primary vulvar Ewing’s sarcoma/PNET have previously been reported.

Methods

We present a patient with primary vulvar Ewing's sarcoma with pulmonary metastasis who presented at the Department of Gynecology and Obstetrics, University of Schleswig-Holstein, Campus Luebeck.

Results

The present report is the third case of a primary vulvar Ewing's sarcoma and the first constellation with pulmonary metastasis at diagnosis in the current literature. We present the diagnostic and therapeutic management including surgery, chemotherapy and radiation.

Conclusion

The treatment of the Ewing’s sarcomas and PNETs requires a multidisciplinary systemic approach. Despite its rarity, the differential diagnosis of vulvar sarcoma must be considered in young women.

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Acknowledgments

PET-CT images by courtesy of Drs. Christian Franke and Andreas Wahl (PET/CT-Centre Hamburg).

Conflict of interest

We declare that we have no conflict of interest. We agree to allow the Journal to review the data if requested.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany

    Katharina Kelling, Christopher Altgassen, Michael K. Bohlmann & Friederike Hoellen

  2. Department of Pathology, University Hospital of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany

    Frank Noack

  3. Department of Surgery, University Hospital of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany

    Peter Kujath

Authors
  1. Katharina Kelling
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  2. Frank Noack
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  3. Christopher Altgassen
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  4. Peter Kujath
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  5. Michael K. Bohlmann
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  6. Friederike Hoellen
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Corresponding author

Correspondence to Friederike Hoellen.

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Kelling, K., Noack, F., Altgassen, C. et al. Primary metastasized extraskeletal Ewing sarcoma of the vulva: report of a case and review of the literature. Arch Gynecol Obstet 285, 785–789 (2012). https://doi.org/10.1007/s00404-011-2011-x

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  • DOI: https://doi.org/10.1007/s00404-011-2011-x

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