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Significance of PTPRZ1 and CIN85 expression in cervical carcinoma

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To investigate PTPRZ1 and CIN85 expression and their significance in cervical carcinoma.

Methods

The expression of PTPRZ1 and CIN85 was detected by immunohistochemistry and the association between PTPRZ1 and CIN85 expression and clinical pathological variables were analyzed.

Results

The expression of PTPRZ1 and CIN85 were significantly higher in cervical carcinoma than those in normal cervical epithelium. CIN85 expression was significantly higher in patients with deeper cervical invasion when compared with that with superficial invasion, while PTPRZ1 expression was significantly higher in patients with smaller tumor size (≤2 cm) than that with larger size (>2 cm). The expression of PTPRZ1 and CIN85 were higher in squamous cell carcinoma than those in adenocarcinoma.

Conclusions

There exist increased PTPRZ1 and CIN85 expression in cervical carcinoma and they are probably associated with tumor growth or invasion. PTPRZ1 and CIN85 expression were higher in squamous cell carcinoma than those in adenocarcinoma.

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Acknowledgments

This work was supported by the Scientific Research Foundation of Education Department of Zhejiang Province, China (Y200908905), Scientific Research Foundation of Ministry of Health, China (wkj2007-2-014) and the Nature Science Foundation of China (30872752).

Conflict of interest

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, People’s Republic of China

    Yaxi Ma

  2. Department of Gynecologic Oncology, The Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, People’s Republic of China

    Feng Ye, Xing Xie, Caiyun Zhou & Weiguo Lu

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  1. Yaxi Ma
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  2. Feng Ye
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  3. Xing Xie
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  4. Caiyun Zhou
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  5. Weiguo Lu
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Corresponding author

Correspondence to Weiguo Lu.

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Ma, Y., Ye, F., Xie, X. et al. Significance of PTPRZ1 and CIN85 expression in cervical carcinoma. Arch Gynecol Obstet 284, 699–704 (2011). https://doi.org/10.1007/s00404-010-1693-9

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  • DOI: https://doi.org/10.1007/s00404-010-1693-9

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