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Gestational sac volume by 3D-sonography at 7–10 weeks of pregnancy using the VOCAL method

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Abstract

Purpose

Establish normative data for gestational sac volume (GSV) between 7 and 10 weeks gestation using three-dimensional ultrasonography (3DUS).

Methods

A cross-sectional study involving 74 normal pregnancies was performed to assess GSV between 7 and 10 weeks gestation. All measurements were performed using an endocavitary volumetric transducer. The virtual organ computer-aided analysis (VOCAL) method was used for volumetric calculations, with a 30° rotation angle. To analyze the correlation between GSV and gestational age, regression models were constructed and adjustments were made using the determination coefficient (R 2). For each week the mean, median, standard-deviation, minimum and maximum GSV values were calculated. The method proposed by Royston and Wright was used to calculate the reference intervals according to crown-rump length (CRL). The interclass correlation coefficient (ICC) and Bland–Altman graph were used to evaluate intraobserver variability.

Results

There was a high correlation between GSV and gestational age (R 2 = 0.816). Mean GSV increased from 8.50 cm3 at 7 weeks to 44.35 cm3 at 10 weeks. There was also a significant correlation between GSV and CRL (R 2 = 0.693) with mean GSV increasing from 5.00 to 50.28 cm3 for CRL between 9 and 40 mm. Intraobserver variability was excellent with an ICC = 0.9997 (95% CI, 0.9994–0.9998), with an average difference between measurements of 0.5 cm3.

Conclusions

There is a correlation between GSV and CRL and this is a reproducible first trimester parameter. Reference limits for GSV using 3DUS were generated for pregnancies between 7 and 10 weeks.

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References

  1. Jansen RP (1982) Spontaneous abortion incidence in the treatment of infertility. Am J Obstet Gynecol 143:451–473

    PubMed  CAS  Google Scholar 

  2. Warburton D, Fraser FC (1964) Spontaneous abortion risks in man: data from reproductive histories collected in a medical genetics unit. Am J Hum Genet 16:1–25

    PubMed  CAS  Google Scholar 

  3. Küçük T, Duru NK, Yenen MC, Dede M, Ergün A, Baser I (1999) Yolk sac size and shape as predictors of poor pregnancy outcome. J Perinat Med 27:316–320. doi:10.1515/JPM.1999.045

    Article  PubMed  Google Scholar 

  4. Laboda LA, Estroff JA, Benacerraf BR (1989) First trimester bradycardia: a sign of impending fetal loss. J Ultrasound Med 8:561–563

    PubMed  CAS  Google Scholar 

  5. Bulic M, Vrtar M (1978) Ultrasonic planimetry of the gestation sac as biometric method in early pregnancy. J Clin Ultrasound 6:228–232. doi:10.1002/jcu.1870060407

    Article  PubMed  CAS  Google Scholar 

  6. Riccabona M, Nelson TR, Pretorius DH (1996) Three-dimensional ultrasound: accuracy of distance and volume measurements. Ultrasound Obstet Gynecol 7:429–434. doi:10.1046/j.1469-0705.1996.07060429.x

    Article  PubMed  CAS  Google Scholar 

  7. Steiner H, Gregg AR, Bogner G, Graf AH, Weiner CP, Staudach A (1994) First-trimester three-dimensional ultrasound volumetry of the gestational sac. Arch Gynecol Obstet 255:165–170. doi:10.1007/BF02335080

    Article  PubMed  CAS  Google Scholar 

  8. Muller T, Sutterlin M, Pohls U, Dietl J (2000) Transvaginal volumetry of first trimester gestational sac: a comparison of conventional with three-dimensional ultrasound. J Perinat Med 28:214–220. doi:10.1515/JPM.2000.029

    Article  PubMed  CAS  Google Scholar 

  9. Lee W, Deter RL, McNie B et al (2006) Quantitative and morphological assessment of early gestational sacs using three-dimensional ultrasonography. Ultrasound Obstet Gynecol 28:255–260. doi:10.1002/uog.2840

    Article  PubMed  CAS  Google Scholar 

  10. Odeh M, Hirsh Y, Degani S, Grinin V, Ofir E, Bornstein J (2008) Three-dimensional sonographic volumetry of the gestational sac and the amniotic sac in the first trimester. J Ultrasound Med 27:373–378

    PubMed  Google Scholar 

  11. Gadelha PS, Da Costa AG, Filho FM, El Beitune P (2006) Amniotic fluid volumetry by three-dimensional ultrasonography during the first trimester of pregnancy. Ultrasound Med Biol 32:1135–1139. doi:10.1016/j.ultrasmedbio.2006.04.015

    Article  PubMed  Google Scholar 

  12. Nowak PM, Nardozza LM, Araujo Júnior E, Rolo LC, Moron AF (2008) Comparison of placental volume in early pregnancy using multiplanar and VOCAL methods. Placenta 29:241–245. doi:10.1016/j.placenta.2007.12.003

    Article  PubMed  CAS  Google Scholar 

  13. Rolo LC, Nardozza LM, Araujo Júnior E, Nowak PM, Moron AF (2008) Yolk sac volume assessed by three-dimensional ultrasonography using the VOCAL method. Acta Obstet Gynecol Scand 87:499–502. doi:10.1080/00016340802011595

    Article  PubMed  Google Scholar 

  14. Royston P, Wright EM (1998) How to construct ‘normal ranges’ for fetal variables. Ultrasound Obstet Gynecol 11:30–38. doi:10.1046/j.1469-0705.1998.11010030.x

    Article  PubMed  CAS  Google Scholar 

  15. Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1:307–310

    PubMed  CAS  Google Scholar 

  16. Trahair JF, Harding R (1992) Ultrastructural anomalies in the fetal small intestine indicates that fetal swallowing is important for normal development: an experimental study. Virchows Arch A Pathol Anat Histophatol 420:305–312

    Article  CAS  Google Scholar 

  17. Zanforlin Filho SM, Araujo Júnior E, Guimarães Filho HA, Pires CR, Nardozza LM, Moron AF (2007) Sonoembryology by three-dimensional ultrasonography: pictorial essay. Arch Gynecol Obstet 276:197–200. doi:10.1007/s00404-007-0330-8

    Article  PubMed  Google Scholar 

  18. Babinszki A, Nyari T, Jordan S, Nasseri A, Mukherjee T, Copperman AB (2001) Three-dimensional measurement of gestational and yolk sac volumes as predictors of pregnancy outcome in the first trimester. Am J Perinatol 18:203–211. doi:10.1055/s-2001-15499

    Article  PubMed  CAS  Google Scholar 

  19. Acharya G, Morgan H (2002) First-trimester, three-dimensional transvaginal ultrasound volumetry in normal pregnancies and spontaneous miscarriages. Ultrasound Obstet Gynecol 19:575–579. doi:10.1046/j.1469-0705.2002.00712.x

    Article  PubMed  CAS  Google Scholar 

  20. Figueras F, Torrents M, Muñoz A et al (2003) Three-dimensional yolk and gestational sac volume. A prospective study of prognosis value. J Reprod Med 48:252–256

    PubMed  Google Scholar 

  21. Robinson HP (1975) Gestational sac volumes as determined by sonar in the first trimester of pregnancy. Br J Obstet Gynaecol 82:100–107

    PubMed  CAS  Google Scholar 

  22. Kupesic S, Kurjak A, Ivancić-Kosuta M (1999) Volume and vascularity of the yolk sac studied by three-dimensional ultrasound and color Doppler. J Perinat Med 27:91–96. doi:10.1515/JPM.1999.010

    Article  PubMed  CAS  Google Scholar 

  23. Peralta CF, Cavoretto P, Csapo B, Falcon O, Nicolaides KH (2006) Lung and heart volumes by three-dimensional ultrasound in normal fetuses at 12–32 weeks’ gestation. Ultrasound Obstet Gynecol 27:128–133. doi:10.1002/uog.2670

    Article  PubMed  CAS  Google Scholar 

  24. Falcon O, Wegrzyn P, Faro C, Peralta CF, Nicolaides KH (2005) Gestational sac volumes measured by three-dimensional ultrasound at 11 to 13 + 6 weeks of gestation: relation to chromosomal defects. Ultrasound Obstet Gynecol 25:546–550. doi:10.1002/uog.1898

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics, São Paulo Federal University (UNIFESP-EPM), São Paulo, SP, Brazil

    Liliam Cristine Rolo, Luciano Marcondes Machado Nardozza, Edward Araujo Júnior, Paulo Martin Nowak & Antonio Fernandes Moron

  2. Rua Carlos Weber, 950 apto. 113 Visage, Alto da Lapa, São Paulo, SP, CEP 05303-000, Brazil

    Edward Araujo Júnior

Authors
  1. Liliam Cristine Rolo
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  2. Luciano Marcondes Machado Nardozza
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  3. Edward Araujo Júnior
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  4. Paulo Martin Nowak
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  5. Antonio Fernandes Moron
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Correspondence to Edward Araujo Júnior.

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Rolo, L.C., Nardozza, L.M.M., Araujo Júnior, E. et al. Gestational sac volume by 3D-sonography at 7–10 weeks of pregnancy using the VOCAL method. Arch Gynecol Obstet 279, 821–827 (2009). https://doi.org/10.1007/s00404-008-0828-8

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  • DOI: https://doi.org/10.1007/s00404-008-0828-8

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