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Ethnicity-stratified analysis of the association between IL-18 polymorphisms and systemic lupus erythematosus in a European population: a meta-analysis

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Abstract

We performed a meta-analysis to identify the association between polymorphisms in the promoter of interleukin-18 (IL-18) and susceptibility for systemic lupus erythematosus (SLE) . Genotype data for three single-nucleotide polymorphisms (SNPs rs360719, rs1946518, and rs187238) in the IL-18 promoter were extracted from 20 studies of three different ethnicities (European, Asian, and South American). Data from each ethnicity group and their combinations were analyzed. We found distinct evidence of an association between rs360719 and SLE (P = 0.001) in the European/South American group [odds ratio (OR) 1.31 per C allele, 95 % confidence interval (CI) 1.11–1.53]. Stratification analysis by ethnicity showed a significant association between rs360719 and SLE in the European population (OR 1.33 per C allele, 95 % CI 1.11–1.61, P = 0.003) and a lesser effect in the same direction in the South American population (OR 1.18). A significant association was also identified between rs1946518 and SLE in the European population (OR 1.16 per A allele, 95 % CI 1.03–1.30, P = 0.017), although there was no association in the Asian or the combined European/Asian population. We also examined genome-wide association study (GWAS) data from an Asian subpopulation (Chinese) for the association between rs1946518 and SLE, but found no association (P = 0.83). The third SNP, rs187238, was not significantly associated with SLE in any of the populations examined. In summary, this study identified a significant association between SLE and two SNPs within the IL-18 gene promoter region (rs360719 and rs1946518) in a European population, but not in populations of Asian origin.

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Acknowledgments

This study was supported by the State Key Development Program for Basic Research of China, 973 Program (2014CB541701), the National Natural Science Foundation of China (81301352), the Zhejiang Provincial Natural Science Foundation of China Grant (LZ13H02001), the HZNUARI-Pilot Research Grant (PD11001006007015), the Medical Science and Technology Program of Shandong Province (2014WS0191) and the Science and Technology Program of Binzhou City (2014ZC0125). The funding agencies had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank the peer reviewers for their thorough and helpful review of this manuscript.

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The authors have no conflicts of interest to declare.

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    Authors and Affiliations

    1. Department of Dermatology, The Third Affiliated Hospital of Anhui Medical University, The First People’s Hospital of Hefei, Anhui, China

      Bi-Rong Guo

    2. Institute of Aging Research, School of Medicine, Hangzhou Normal University, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China

      Jing-Jing Rong, Wen-Ying Zhong, Ming Liu, Wei Li, Xiao-Bo Wang, Li Wang & Hou-Feng Zheng

    3. Department of Dermatology, The Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong, China

      Yi-Hua Wei

    4. Department of Emergency, The Third Affiliated Hospital of Anhui Medical University, The First People’s Hospital of Hefei, Anhui, China

      Cong-Sheng Li

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    B.-R. Guo, J.-J. Rong and Y.-H. Wei contributed equally to this work.

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    Guo, BR., Rong, JJ., Wei, YH. et al. Ethnicity-stratified analysis of the association between IL-18 polymorphisms and systemic lupus erythematosus in a European population: a meta-analysis. Arch Dermatol Res 307, 747–755 (2015). https://doi.org/10.1007/s00403-015-1580-0

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